Differences of group B streptococcus infection in the third trimester and its impact on pregnancy outcomes and neonates
Objective To analyze the differences of group B streptococcus(GBS)infection in the third trimester and its impact on pregnancy outcomes and neonates.Methods A retrospective selection of 300 pregnant women in the third trimester who gave birth in the Suzhou BENQ Medical Center from January 2017 to December 2019,vaginal and rectal secretions were collected for GBS screening at 35-37 weeks for gestational age,and divided into GBS+group(n=72)and GBS-group(n=228)according to GBS infection;all of whom underwent GBS infection detection,vaginal cleanliness detection and serum inflammatory index detection[interleukin-6(IL-6),procalcitonin(PCT)],observation of perinatal indicators(delivery time,postpartum hemorrhage,neonatal weight)of the two groups of the subjects and maternal and infant outcomes(pregnancy outcomes,neonatal disease).Results There was no significant difference in the incidence of GBS+in the vaginal secretions and rectal secretions of the enrolled subjects(x2=2.828,P＞0.05).Both vaginal and rectal secretions had less GBS+incidence than combined test(x2=17.558,6.551;all P＜0.05).The incidence of abnormal vaginal cleanliness in GBS+group was 62.50％,which was higher than 41.23％in GBS-group,and the difference was statistically significant(x2=9.958,P＜0.05).The serum IL-6 and PCT contents in GBS+group were higher than those in GBS-group(x2=43.959,14.763;all P＜0.05).There was no significant difference in delivery time,postpartum hemorrhage and neonatal weight between GBS+group and GBS-group(x2=0.440,-0.930,1.627;all P＞0.05).The incidence of prematurity,premature rupture of membranes,puerperium infection,and intrauterine infection in the GBS+group were higher than those in the GBS-group,the differences were statistically significant(x2=4.678,16.859,4.402,6.331;all P＜0.05);the incidences of neonatal asphyxia,neonatal infection,neonatal pneumonia,neonatal sepsis and neonatal jaundice in the GBS+group were higher than those in the GBS-group(x2=11.817,10.498,18.111,9.596,27.433;all P＜0.05).Conclusions Combined vaginal and rectal secretions were more effective for GBS in the third trimester of pregnancy.GBS+patients had poorer vaginal cleanliness,higher serum inflammatory factor levels,and were more likely to have adverse maternal and infant outcomes.
Group B streptococcus infectionThird trimesterPregnancy outcomeNeonatal disease
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