Postoperative infection,pathogens distribution and drug resistance characteristics in patients undergoing allogeneic transfusion
Objective To analyze postoperative infection,pathogens distribution and drug resistance characteristics in patients undergoing allogeneic transfusion in order to guide clinical rational use of antibiotics.Methods A total of 80 patients undergoing allogeneic transfusion in the Surgery Department of the Changzhou Hospital of Traditional Chinese Medicine were retrospectively enrolled as the research objects between May 2020 and April 2023.The postoperative infection in patients was statistically analyzed.The clinical data in infection group(n=21)and non-infection group(n=59)were compared.The pathogens distribution and drug resistance characteristics in infection patients were analyzed.Results In the 80 patients after allogeneic transfusion,the incidence of infection was 26.25％.There were significant differences in erythrocytes transfusion,allogeneic transfusion timing,allogeneic transfusion volume and storage time of erythrocytes component between infection group and non-infection group(x2=11.719,7.590,6.432,7.882;all P＜0.05).In infection patients,there were 29 strains of pathogens,including Gram-negative bacteria(62.07％,including Escherichia coli,Pseudomonas aeruginosa and Klebsiella pneumoniae),Gram-positive bacteria(31.03％,including Staphylococcus haemolyticus and Staphylococcus epidermidis)and fungi(6.90％).Escherichia coli and Klebsiella pneumoniae were almost not resistant to piperacillin/tazobactam or meropenem,and their resistance rates to ampicillin sulbactam and ceftriaxone were relatively higher.The resistance rates of Staphylococcus hemolyticus and Staphylococcus epidermidis were relatively higher to penicillin G and erythromycin,especially to penicillin G(100％),but they were almost not resistant to linezolid and vancomycin.Conclusions The incidence of postoperative infection was high in patients undergoing allogeneic transfusion,and Escherichia coli was the most common in Gram-negative bacteria.In clinical practice,it should be necessary to comprehensively consider epidemic characteristics and drug resistance of pathogens in the hospital when selecting empirical antibacterial therapy if there were no blood culture and drug resistance results.
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