Serum 25-hydroxyvitamin D levels in patients with pertussis
Objective To investigate the 25-hydroxyvitamin D[25(OH)D]level of pertussis patients and explore the correlation between 25(OH)D level and pertussis.Methods A total of 255 pertussis patients diagnosed in the Xi'an Children's Hospital from January to December 2021 were enrolled as the pertussis group and 765 healthy children who underwent physical examination during the same period were enrolled as the healthy control group.According to the severity of the disease,the patients were divided into the common pertussis group(n=244)and the severe pertussis group(n=11).The serum 25(OH)D levels of each group were detected,and the correlation between pertussis and serum 25(OH)D was further analyzed according to gender,age and season.Results There was no significant difference in sex,age and season distribution between pertussis group and healthy control group(all P＞0.05).25(OH)D level of pertussis group[20.73(10.96,35.62)ng/mL]was significantly lower than that of healthy control group[29.00(20.09,45.66)ng/mL],the difference was statistically significant(Z=-7.643,P＜0.05).The serum 25(OH)D level in the pertussis group was lower than that in healthy control group in different gender and age,the differences were statistically significant(all P＜0.05).The 25(OH)D levels in the pertussis group in autumn and winter were significantly lower than those in the healthy control group,and the differences were statistically significant(Z=-8.273,-8.904,bothP＜0.05);there was no statistically significant difference in 25(OH)D levels between the pertussis group and the healthy control group in spring and summer(Z=-0.868,-0.292,both P＞0.05).There was a statistically significant difference in the composition ratio of vaccination doses between the pertussis group and the healthy control group(x2=12.489,P＜0.05).The age of onset of pertussis had two peaks,which were less than 1 year old and 6 to 8 years old.The age of the severe pertussis group was lower than that of the common pertussis group,and the difference was statistically significant(Z=-3.972,P＜0.05);the difference in 25(OH)D levels between the two groups was not statistically significant(Z=-1.783,P＞0.05).Conclusion Patients with pertussis generally had low vitamin D levels,and reduced vitamin D levels might lead to increased susceptibility after exposure to Bordetella pertussis.
NETL
NSTL
万方数据
