Clinical value of PLR and platelet-related parameters in early malaria infection
Objective To study the clinical value of platelet lymphocyte rate(PLR)and related parameters of peripheral blood platelets in early malaria infection.Methods From January to April 2021,43 malaria patients(malaria group)and 43 healthy patients(healthy control group)in the Republic of Mali were collected,and blood routine and peripheral blood smear tests were performed.The lymphocyte absolute value(LYM),platelet(PLT),PLR,platelet distribution width(PDW)and mean platelet volume(MPV)were compared between the two groups,and the risk factors of malaria were determined by multivariate logistic regression analysis.The predictive value of PLR and PDW for malaria was evaluated by receiver operating characteristic(ROC)curve.Results The levels of PLR and PLT in the malaria group[(64.69±4.73),(181.70±9.90)×109/L]were significantly lower than those in the healthy control group[(134.50±13.03),(285.50±11.87)× 109/L],the differences were statistically significant(t=5.033,36.716;both P＜0.001);while the levels of PDW and MPV[(13.55±0.35),(11.12±0.19)fL]were significantly higher than those in the healthy control group[(12.32±0.31),(10.55± 0.16)fL],the differences were statistically significant(t=2.632,2.289;both P＜0.05).Decreased PLR(OR=0.949,95％CI:0.949-0.984)and increased PDW(OR=1.362,95％CI:1.048-1.771)were independent risk factors for malaria.The area under curve(AUC)of PLR and PDW for predicting malaria were 0.828 and 0.657,respectively.The AUC of the combined prediction was 0.852 and the diagnostic efficiency was higher than that of the single index.Conclusion The decrease of PLR and the increase of PDW and MPV have certain clinical value for the diagnosis of early malaria infection,which is beneficial for the initial screening of malaria in the areas where malaria is prevalent and medical conditions are not developed.
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