Detection value of serum TNF-α,IL-6,IFN-γ and CD3+,CD4+,CD8+in children infected with influenza virus in Kawasaki disease
Objective To study the detection value of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-y(IFN-γ)and CD3+,CD4+,CD8+in children infected with influenza virus in Kawasaki disease.Methods A total of 30 cases of Kawasaki disease with influenza virus infection treated in Harrison International Peace Hospital from October 2016 to March 2020 were selected as Kawasaki disease combined with influenza group,100 cases of uninfected influenza virus were selected as simple Kawasaki disease group,and 100 cases of influenza virus children were selected as simple influenza group.Serum levels of TNF-α,IL-6,IFN-γ and CD3+,CD4+,CD8+,CD4+/CD8+were analyzed,and the predictive value of serum TNF-α,IL-6,IFN-γ and CD3+,CD4+,CD8+,CD4+/CD8+in Kawasaki disease combined with influenza virus infection was analyzed by receiver operating characteristic(ROC)curve.Results Serum levels of TNF-α,IL-6,IFN-γ,CD3+,CD4+,CD8+,CD4+/CD8+in Kawasaki disease combined with influenza group were significantly higher than those in simple Kawasaki disease group and simple influenza group;Serum levels of TNF-α,IL-6,IFN-γ,CD3+,CD4+,CD8+,CD4+/CD8+in simple Kawasaki disease group were significantly higher than those in simple influenza group,the differences were statistically significant(F=135.714,546.752,110.467,254.770,300.654,22.686,37.603;all P＜0.05).The proportion of coronary artery damage and fever duration[46.67％,(11.35±4.31)d]in Kawasaki disease combined with influenza group were significantly higher than that in simple Kawasaki disease group[19.00％,(6.25±2.13)d],and the differences were statistically significant(t=9.326,x2=8.819;both P＜0.05).ROC results showed that the area under the curve(AUC)of serum TNF-α,IL-6,IFN-γ,CD3+,CD4+,CD8+,CD4+/CD8+for predicting Kawasaki disease combined with influenza virus infection were 0.779,0.993,0.819,0.769,0.634,0.831,0.964,respectively.The cut-off values were 11.43 μg/L,50.89 μg/L,16.26 μg/L,79.72％,38.74％,3.75％and 4.48,respectively,with statistical significance(all P＜0.05).Conclusion The serum levels of TNF α,IL-6,IFN-γ and T cell immune expression were abnormal in Kawasaki disease combined with influenza virus infection,which had certain predictive value and clinical application value in the occurrence of Kawasaki disease combined with influenza virus infection.
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