Relationship between serum HBV-DNA load,glucose and lipid metabolism and adverse pregnancy outcomes in patients with GDM combined with HBV infection
Objective To investigate the Relationship between serum HBV-DNA load,glucose and lipid metabolism and adverse pregnancy outcomes in patients with gestational diabetes mellitus(GDM)combined with hepatitis B virus(HBV)infection.Methods A total of 120 pregnant women with GDM who gave birth in the Zhoukou Maternal and Child Health Hospital between December 2019 and December 2021 were selected.According to the presence or absence of HBV infection,the subjects were divided into symptomatic HBV infection group(n=40),asymptomatic HBV infection group(n=40)and simple GDM group(n=40).Meanwhile,40 healthy pregnant women were selected as the health group.Serum HBV-DNA load was compared between the symptomatic HBV infection group and the asymptomatic HBV infection group.Fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC),leptin(LP)and adiponectin(ADPN)levels,and adverse pregnancy outcomes of the four groups were comparatively analyzed.The relationship of serum HBV-DNA load with glucose and lipid metabolism and adverse pregnancy outcomes in patients with GDM and HBV infection was analyzed.Results The HBV-DNA load of the symptomatic HBV infection group[(8.86±1.5)lg copy/mL)]was significantly higher than that of the asymptomatic HBV infection group[(7.19±1.32)lg copy/mL)],the difference was statistically significant(t=6.992,P＜0.05).With the aggravation of HBV infection,the levels of FPG,HbA1c,TG,TC and LP increased,and the level of ADPN decreased;there were significant differences among health group,simple GDM group,asymptomatic HBV infection group and symptomatic HBV infection group(F=80.802,56.430,4.882,23.987,49.074,24.452;all P＜0.05).The total incidence rates of adverse pregnancy outcomes in the health group,simple GDM group,asymptomatic HBV infection group,symptomatic HBV infection group were 2.50％,20.00％,32.50％and 42.50％,respectively,the difference was statistically significant(x2=22.072,P＜0.05).Pearson correlation analysis showed that serum HBV-DNA load of patients with GDM and HBV infection was positively correlated with LP and negatively correlated with ADPN(r=0.325,-0.259,both P＜0.05).Conclusions Serum HBV-DNA load of patients with GDM and HBV infection increased with the aggravation of HBV infection.Serum HBV-DNA load was positively correlated with LP and negatively correlated with ADPN.
Gestational diabetes mellitusHepatitis B virusHBV-DNAGlucose and lipid metabolismAdverse pregnancy outcome
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