Changes of POSTN and Ki67 expression levels in patients with multiple myeloma and their correlation with prognostic
Objective To explore the expression of periostin(POSTN)and Ki67 in the plasma of multiple myeloma(MM)patients and analyze their correlation with prognosis.Methods A total of 88 patients with MM admitted to Suining Central Hospital from June 2018 to April 2021 were retrospectively studied,MM patients were classified as stage Ⅰ(n=22),stageⅡ(n=30)and stage Ⅲ(n=36)according to R-ISS.Forty healthy volunteers mathched for basic clinical information served as the control group.The expression levels of POSTN and Ki67 in peripheral blood were determined by RT-qPCR,and the prognosis and recurrence of the patients were evaluated after 6 months of follow-up.The survival curve,Kaplan-Meier method and log-rank test were used to analyze the POSTN and Ki67 levels and the prognosis and survival status of the two groups of patients.Results The levels of serum β2 microglobulin and lactate dehydrogenase in MM patients of stage Ⅰ,Ⅱ and Ⅲ were significantly higher than those in the control group,while the levels of albumin were significantly lower,the differences were statistically significant(F=244.298,283.843,881.190;all P＜0.001).The levels of plasma POSTN and Ki67 mRNA were significantly higher than those in the control group,the differences were statistically significant(F=159.068,396.522;all P＜0.05).At the last follow-up,the overall survival and progression-free survival in stage Ⅰ patients were(26.41±5.75)months and(23.75±7.25)months,respectively;those in stage Ⅱ patients were(24.57±8.33)months and those in stage Ⅲ patients were(20.27±8.87)months,and those in stage Ⅲ patients were(22.19±8.75)months and those in stage Ⅲ patients were(17.43±8.63)months.The overall survival rate of stage Ⅰ patients was 68.18％(15/22),which was significantly higher than that of stage Ⅱ patients(63.33％,19/30)and stage Ⅲ patients(55.56％,20/36).Pearson correlation analysis showed that plasma POSTN and Ki67 mRNA levels were significantly negatively correlated with overall survival time(r=-0.473,-0.385;all P＜0.001)and progression-free survival time(r=-0.519,-0.548;all P＜0.001).Conclusions The levels of plasma POSTN and Ki67 mRNA were significantly negatively correlated with the survival time of MM patients,which had important guiding significance for the evaluation of disease progression and prognosis of MM patients.
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