Significance of detecting serum amyloid A and high-sensitivity C-reactive protein levels in early stage of infectious diseases in children
Objective To investigate the changes of serum amyloid A(SAA)and hypersensitive C-reactive protein(hs-CRP)levels in the early stage of infective diseases in children and their diagnostic value.Methods A total of 116 children with infectious diseases admitted to the Gansu Provincial Maternal and Child Health Care Hospital from January 2022 to December 2022 were selected as research objects.And based on the results of pathogen testing,they were divided into viral infection group(n=77)and bacterial infection group(n=39).Another 40 children who underwent health examination in our hospital during the same period were selected as control group.The serum levels of SAA,hs-CRP and SAA/hs-CRP were compared in the three groups of children at the early stage of infection,and the application value of single and combined detection of SAA,hs-CRP and SAA/hs-CRP in the early diagnosis and treatment of infantilism was evaluated.Results The levels of serum SAA and hs-CRP in the three groups were bacterial infection group＞viral infection group＞control group,the differences were statistically significant(F=5 020.659,632.763;all P＜0.05).The level of SAA/hs-CRP was virus infection group＞bacterial infection group＞control group,the differences were statistically significant(F=334.038,P＜0.05).Serum levels of SAA,hs-CRP,SAA/hs-CRP,WBC,NEUT％,LYM％were risk factors for early diagnosis of infective diseases in children(all P＜0.05).ROC analysis results showed that the areas under the curve of serum SAA,hs-CRP and SAA/hs-CRP for distinguishing early childhood infectious diseases were 0.721,0.741,0.883 and 0.921 respectively.Conclusion Serum SAA,hs-CRP,SAA/hs-CRP combined detection had good application value in early identification and diagnosis of infective diseases in children,and could provide an important basis for clinical anti-infective treatment.
Pediatric infectious diseasesSerum amyloid AHypersensitive C-reactive protein
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