Predictive value of serum IL-18,IL-33 combined with PTX-3 on pregnancy outcomes in preeclampsia pregnant women
Objective To analyze the predictive value of serum interleukin-18(IL-18),IL-33 combined with pentraxin-3(PTX-3)on pregnancy outcomes in preeclampsia pregnant women.Methods From February 2021 to April 2023,110 pregnant women with preeclampsia who visited Cangzhou People's Hospital were collected and included in the preeclampsia group.Meantime,60 pregnant women who had normal prenatal examinations from February 2021 to April 2023 were regarded as the normal group.The serum levels of IL-18,IL-33,PTX-3,and adverse pregnancy outcomes were compared between the normal group and the eclampsia group;the preeclampsia group was separated into a good pregnancy group(n=71)and an adverse pregnancy group(n=39)based on pregnancy outcomes;the data and the levels of IL-18,IL-33,and PTX-3 were compared;the factors affecting the pregnancy outcomes of preeclampsia pregnant women and their predictive value for adverse pregnancy outcomes were analyzed.Results The levels of IL-18(49.83±5.08)ng/L and PTX-3(2.77± 0.31)pg/L in the preeclampsia group were higher than those in the normal group(45.08±4.55)ng/L,(1.31±0.15)μg/L,while IL-33 level(21.44±2.46)ng/L was lower than that in the normal group(29.69±3.13)ng/L,the differences were statistically significant(t=6.040,34.322,18.939;all P＜0.05).There were 39 cases with adverse pregnancy outcomes in the eclampsia group,with an incidence rate of 35.45％,which was higher than the incidence rate of 8.33％in the normal group,the differences was statistically significant(P＜0.05).Poor pregnancy group was different from good pregnancy group in age,gestational age,systolic and diastolic blood pressure,24-hour urine protein quantification,blood urea nitrogen,blood creatinine,IL-18,IL-33,and PTX-3(P＜0.05).Logistic regression analysis showed that IL-18,IL-33,and PTX-3 were the influencing factors of pregnancy outcomes in the preeclampsia group(P＜0.05).The AUC(0.922)of the combined prediction of IL-18,IL-33,and PTX-3 for adverse pregnancy outcomes in preeclampsia pregnant women was greater than the AUC(0.765,0.766,0.764)predicted by IL-18,IL-33,and PTX-3,respectively(Zcombined vs.IL-18=2.901,P=0.004;Zcombined vs.IL-33=3.092,P=0.002;Zcombined vs.PTX-3=2.655,P=0.008).Conclusion Serum IL-18,IL-33,and PTX-3 levels had certain predictive value for pregnancy outcomes in preeclampsia pregnant women,and the combined detection had higher predictive value.
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