Levels and prognostic value of serum lncRNA XIST and lncRNA SOX2OT in elderly patients with acute cerebral infarction
Objective To investigate the serum levels of long non-coding RNA chromosome X inactivate-specific transcripts(lncRNA XIST)and long non-coding RNA SOX2 overlapping transcript(lncRNA SOX2OT)in elderly patients with acute cerebral infarction and their prognostic value.Methods From February 2021 to February 2023,154 elderly ACI patients admitted to our hospital were collected as the study subjects.The patients were separated into a good group(n=111)and an adverse group(n=43)using mRS scores.Additionally,160 healthy individuals who underwent physical examination were regarded as the healthy group.qRT-PCR was applied to analyze the serum levels of lncRNA XIST and lncRNA SOX2OT in patients;multivariate logistic regression was applied to analyze the factors influencing poor prognosis of patients;Spearman method was applied for correlation analysis.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum lncRNA XIST and lncRNA SOX2OT levels for prognosis.Results The level of lncRNA XIST(0.47±0.09)vs.(0.61±0.09)vs.(1.01±0.27)in the poor prognosis group was lower than that in the good group and healthy group,and the level of lncRNA SOX2OT(2.16±0.37)vs.(1.73±0.33)vs.(1.03±0.21)levels were higher than those in the good group and healthy group,the differences were statistically significant(F=190.845,367.704;all P＜0.001).The mRS score(1.52±0.37)vs.(3.79±0.45)and NIHSS score(3.57±1.11)vs.(9.72±3.12)in the good prognosis group were significantly lower than those in the poor prognosis group,the differences were statistically significant(t=32.097,18.092,all P＜0.001).lncRNA XIST was negatively correlated with mRS score and NIHSS score(r=-0.503,-0.479;all P＜0.001).lncRNA SOX2OT was positively correlated with mRS score and NIHSS score(r=0.525,0.493;all P＜0.001).lncRNA XIST and lncRNA SOX2OT were factors affecting patient prognosis(all P＜0.05).The area under the curve(AUC)of serum lncRNA XIST and lncRNA SOX2OT combined diagnosis of patient prognosis was 0.920,which was significantly higher than those of individual diagnosis(ZlncRNA XIST vs.combination=2.123,P=0.034;ZlncRNA SOX2OT vs.combination=2.108,P=0.035);the sensitivity of the joint diagnosis was 90.99％,and the specificity was 79.07％.Conclusion The serum lncRNA XIST level was down regulated and lncRNA SOX2OT level was up regulated in ACI patients,and they were closely related to prognosis.
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