Correlation analysis of serum Hcy,CysC and Met with thyroid nodules in patients with type 2 diabetes mellitus
Objective To investigate the correlation between serum homocysteine(Hcy),cystatin C(Cys-C),methionine(Met)and thyroid nodules in patients with type 2 diabetes mellitus(T2DM).Methods A total of 116 patients with T2DM admitted to the Department of Endocrinology,967th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from January to December 2022 were selected and divided into thyroid nodule group(n=75)and non-thyroid nodule group(n=41)according to whether there were thyroid nodules.The general clinical data,biochemical indexes,Hcy,Cys-C and Met levels of the two groups were compared,and the data were statistically analyzed.Results The levels of Hcy and Cys-C in the thyroid nodule group were higher than those in the non-thyroid nodule group,and the Met level was lower than that in the non-thyroid nodule group,and the differences were statistically significant(Z=-2.550,-1.973,-2.264;all P＜0.05).Spearman correlation analysis showed that Hcy and Cys-C were positively correlated with T2DM with thyroid nodules(r=0.238,0.184;all P＜0.05),Met was negatively correlated with T2DM with thyroid nodules(r=-0.211,P＜0.05),and Hcy was positively correlated with Cys-C(r=0.420,P＜0.01).Multivariate unconditional logistic regression analysis showed that Hcy and Met were independent risk factors and protective factors for the risk of thyroid nodules in T2DM,respectively(OR=1.247,0.896;all P＜0.05).The analysis of receiver operating characteristics(ROC)curve showed that the area under the curve(AUC)of Hcy and Met in predicting thyroid nodules were 0.644(95％CI:0.543-0.745,P＜0.05)and 0.627(95％CI:0.520-0.735,P＜0.05),respectively,and the best cut-off values of Hcy and Met in predicting the diagnosis of T2DM complicated with thyroid nodules were 12.02 and 23.57 μmol/L,and the predictive value of combined detection in the diagnosis of T2DM complicated with thyroid nodules was the highest,AUC was 0.706(95％CI:0.609-0.803,P＜0.01).Conclusion The occurrence of thyroid nodules in patients with T2DM was closely related to the levels of Hcy,Cys-C and Met;Hcy and Met might be independent predictors of thyroid nodules in T2DM,and the combined detection has a high predictive value for the development of thyroid nodules in T2DM.
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