Epidemiological and clinical characteristics of 754 hospitalized adults with dengue fever
Objective To analyze the clinical characteristics of 754 adult dengue inpatients in Guangzhou and Xishuangbanna,and provide reference for clinical diagnosis,treatment and population prevention and treatment of dengue fever.Methods The general data,laboratory examination and clinical manifestations of 754 adult dengue inpatients admitted to the Guangzhou Eighth People's Hospital,the Xishuangbanna Dai Autonomous Prefecture People's Hospital,the Xishuangbanna Mental Health Prevention and Control Center and the Menghai County Daluo Town Central Health Center from January 2018 to December 2019 were retrospectively analyzed.The clinical and pathogenic characteristics of dengue fever were analyzed descriptively.Results Among 754 patients,219 cases were complicated with underlying diseases.The peak age of onset was 18-59 years old,accounting for 77.59％(585/754).The peak time of onset was from August to November,with 688(91.25％)local cases and 66(8.75％)imported cases.The common clinical manifestations were fever(94.16％,710/754),bone/joint/muscle soreness(60.21％,454/754),headache(50.80％,382/754),digestive tract symptoms and respiratory tract symptoms were also more common.The 329 cases were classified as type Ⅰ(68.69％,226/329),type Ⅱ(28.27％,93/329),type Ⅲ(3.98％,9/329),and type Ⅳ(0.30％,1/329).The main findings of laboratory examination were decreased white blood cell count(63.12％,476/754),increased RBC(30.2％,145/480),decreased platelet count(72.28％,545/754),and increased lactate dehydrogenase(67.64％,510/754),alanine aminotransferase(49.20％,371/754)and aspartate aminotransferase(74.14％,559/754).678 cases(89.92％)were improved or recovered,and 76 cases(10.08％)were transferred to severe condition.Conclusion The clinical manifestations of dengue fever inpatients in Guangzhou and Xishuangbanna in 2018-2019 were in line with the general pattern of dengue fever occurrence and development,with dengue virus type Ⅰ infection predominating,and most patients had a good prognosis after symptomatic supportive treatment and active prevention and control of complications.
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