Prognostic value of CX3CL1,FIB and MPV/PLT in patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To investigate the prognostic value of CX3 chemokine ligand 1(CX3CL1),fibrinogen(FIB)and mean platelet volume/platelet count(MPV/PLT)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 114 patients with AECOPD admitted to the First Affiliated Hospital of Guangdong Pharmaceutical University from June 2021 to June 2023 were selected as the study objects,and were divided into a survival group(91 cases)and a death group(23 cases)according to their prognosis.The independent influencing factors of AECOPD patients'prognosis were analyzed by univariate and multivariate analysis,and the predictive value of CX3CL1,FIB,MPV/PLT on the prognosis of AECOPD patients and their influence on the survival of patients were analyzed.Results In the death group,mechanical ventilation rate,C-reactive protein(CRP),neutrophil count(NEU),CX3CL1,MPV,FIB levels were higher than those of the survival group;PLT level was lower than that of the survival group;the differences were statistically significant(x2/t=7.992,5.542,3.240,5.762,3.188,4.545,4.309;all P＜0.05).MPV/PLT level in the death group(0.07±0.01)was significantly higher than that in the survival group(0.04±0.01),the differences were statistically significant(t=7.904,P＜0.001).Logistic analysis showed that mechanical ventilation,CRP,NEU,MPV,CX3CL1,MPV/PLT and FIB levels were the risk factors for death in AECOPD patients,and PLT level was the protective factor for death in AECOPD patients(P＜0.05).Receiver operating characteristic(ROC)analysis results showed that the AUC of CX3CL1,FIB and MPV/PLT single and combined detection for prognosis of AECOPD patients were 0.870,0.754,0.832 and 0.957,respectively,and combined prediction was better than single prediction,the differences were statistically significant(P＜0.001).The cumulative survival rates of patients with high expression levels of CX3CL1(Log-rank x2=34.872,P＜0.001),FIB(Log-rank x2=16.543,P＜0.001),and MPV/PLT(Log-rank x2=28.750,P＜0.001)were lower than those with low expression levels,the differences were statistically significant.Conclusion CX3CL1,FIB,MPV/PLT levels combined detection had high prognostic value in AECOPD patients,and the expression levels of CX3CL1,FIB,MPV/PLT were related to the survival time and survival rate of patients.
NETL
NSTL
万方数据
