Prognostic value of easy albumin-bilirubin score for radical surgery in patients with gallbladder carcinoma
Objective To explore the clinical value of easy albumin-bilirubin(EZ-ALBI)score as a prognostic index in patients with gallbladder carcinoma(GBC)after surgery.Methods The complete clinical and pathological data of 126 GBC patients admitted to the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Kunming Medical University from June 2015 to September 2021 were retrospectively analyzed.According to EZ-ALBI score,126 GBC patients were divided into low EZ-ALBI score group(score≤-34.4)(n=103)and high EZ-ALBI score group(score＞-34.4)(n=23).The relationship between EZ-ALBI score and clinicopathological factors was analyzed.The survival curve of patients was plotted by Kaplan-Meier method,and the Cox proportional hazard model was used to analyze the impact of clinicopathological factors on prognosis.Results The EZ-ALBI score was correlated with gallstones(x2=5.041,P=0.025),lymphocyte(Z=-3.856,P＜0.001),hemoglobin(Z=-2.123,P=0.034),serum total bilirubin(Z=-7.329,P＜0.001),serum albumin(Z=-6.325,P＜0.001),alkaline phosphatase(Z=-5.034,P＜0.001)and CA199(Z=-3.462,P=0.001)levels,but not with other clinicopathological factors such as age and gender(all P＞0.05).The 1-year survival rates of the high EZ-ALBI score group and the low EZ-ALBI score group were 52.2％and 79.6％,respectively,and the difference was statistically significant(x2=7.471,P=0.006).EZ-ALBI score[HR=0.169,95％CI(0.051-0.560),P=0.004],hemoglobin level[HR=0.986,95％CI(0.974-0.998),P=0.020],and the presence or absence of lymphatic metastases[HR=1.906,95％CI(1.091-3.330),P=0.023]were independent risk factors for the prognosis of radical resection in patients with GBC.Conclusion The EZ-ALBI score could be used as an independent prognostic factor to evaluate the prognosis of gallbladder cancer patients,and the patients with high EZ-ALBI score had poor prognosis.
Gallbladder carcinomaEasy albumin-bilirubinRadical surgery
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