Effects of tripterygium glycosides on infection risk in patients with CRF undergoing PD
Objective To analyzed the effects of tripterygium glycosides on infection risk in patients with chronic renal failure(CRF)undergoing peritoneal dialysis(PD),provided the basis for clinical treatment.Methods A total of 196 patients with CRF in the Nanyang Central Hospital were enrolled and randomly divided into control group(PD)and observation group(tripterygium glycosides combined with PD)between January 2020 and June 2022,98 cases in each group.The curative effect,infection risk,renal function,immunity and microinflammation state in the two groups were compared before and after treatment.Results The total response rate in observation group was higher than that in control group[90.82%(89/98)vs.80.61%(79/98)],and incidence of peritoneal dialysis-related peritonitis(PDRP)was lower than that in control group[1.02%(1/98)vs.7.14%(7/98)];the differences were statistically significant(c2=4.167,4.691;all P<0.05).After treatment,levels of blood urea nitrogen(BUN),24 h urinary protein(UTP)and creatinine(Scr)in observation group were lower than those in control group;the differences were statistically significant(t=10.823,13.019,8.899;all P<0.05).After treatment,CD3+,CD4+and CD4+/CD8+in observation group were higher than those in control group,the differences were statistically significant(t=7.171,7.504,4.665;all P<0.05).After treatment,levels of serum interleukin(IL)-8,IL-6 and tumor necrosis factor-α in observation group were lower than those in control group;the differences were statistically significant(t=14.259,24.666,17.725;all P<0.05).Conclusion The curative effect of tripterygium glycosides was significant on PD patients with CRF,which could reduce infection risk,improve renal function,promote immunity recovery and alleviate microinflammation state.
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