Significance of combined detection of serum TSH,FT3 and PCT in the diagnosis of neonatal infectious diseases
Objective To detect the expression of serum thyroid-stimulating hormone(TSH),free total triiodothyronine(FT3)and procalcitonin(PCT)in neonates with infectious diseases,and explore the significance of the combination of the above serum indicators in the diagnosis of neonatal infectious diseases.Methods A total of 100 febrile newborns treated in the Department of Neonatology of Yiling People's Hospital from March 2019 to March 2022 were selected as the study group.According to the type of infection,they were grouped into bacterial infection group(46 cases)and viral infection group(54 cases).And according to the neonatal critical illness scoring standard,they were divided into non-critical group(38 cases),critical group(28 cases)and extremely critical group(34 cases).Another healthy 50 children with no abnormality were selected as the control group.The expression levels of serum TSH,FT3 and PCT in infants and young children in the above study group and control group were measured respectively,and the differences of each index were compared and analyzed.Logistic regression was used to analyze the influencing factors of neonatal infectious diseases.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic performance of the above indicators for neonatal infectious diseases.Results The levels of serum TSH and PCT in the bacterial infection group were higher than those in the virus infection group;all the differences were statistically significant(t=7.626,9.866;all P<0.05),and the level of serum FT3 was lower than that in the virus infection group;the difference was statistically significant(t=10.654,P<0.05).With the aggravation of the disease,the expression levels of serum TSH and PCT increased(F=31.449,69.274),and the level of FT3 decreased(F=60.396);there were significant differences among the control group,non-critical group,critical group and extremely critical group(all P<0.05).The areas under the curve(AUC)of TSH,FT3,PCT and their combination for the diagnosis of neonatal infectious diseases were 0.875,0.867,0.911,and 0.966,respectively;the AUC of the three combined diagnosis was higher than that of the single index independent diagnosis(Z=3.137,3.579,2.749,P=0.002,<0.001,0.006).The combined sensitivity of the three was 90.00%,and the specificity was 92.00%.Conclusion The combination of TSH,FT3 and PCT had high value in the diagnosis of neonatal infectious diseases,and had reference value for judging the pathogenic bacteria of infection and the severity of the disease in children.
Infectious diseases of neonatesThyroid stimulating hormoneFree total triiodothyronineProcalcitonin
NETL
NSTL
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