The diagnostic value of serum PCT,hs-CRP,and IL-17 levels in elderly COPD patients with lower respiratory tract infections
Objective To investigate the serum levels of procalcitonin(PCT),high sensitivity C-reactive protein(hs-CRP),and interleukin-17(IL-17)in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with lower respiratory tract infection,and analyze the diagnostic and prognostic value of the examination results.Methods A retrospective study was conducted on 120 elderly COPD patients in Ningguo People's Hospital from August 2019 to August 2023.They were divided into merging group(with lower respiratory tract infection,n=68)and control group(without lower respiratory tract infection,n=52)based on whether they were complicated with lower respiratory tract infection.Among them,merging group patients were divided into poor prognosis group(poor prognosis:readmission for treatment due to disease recurrence,n=27)and good prognosis group(good prognosis:normal life without recurrence,n=41)based on the 60 day follow-up results after treatment.On the second day after admission,serum levels of PCT,hs-CRP,and IL-17 were detected in all enrolled study subjects to analyze the diagnostic and prognostic value of these indicators for elderly COPD patients with lower respiratory tract infections.Results The serum levels of PCT,hs-CRP,and IL-17 in merging group were significantly higher than those in control group,the differences were statistically significant(t=4.345,12.528,8.011;all P<0.001).The receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)of serum PCT,hs-CRP,and IL-17 for diagnosing COPD complicated with lower respiratory tract infection were 0.721(95%CI:0.631-0.799),0.750(95%CI:0.663-0.824),and 0.759(95%CI:0.672-0.832),respectively.The combined AUC of the three was 0.905(95%CI:0.838-0.951),and the AUC value of the combined indicator diagnosis was higher than that of the single indicator diagnosis(all P<0.05).The levels of serum PCT,hs-CRP,and IL-17 in poor prognosis group were significantly higher than those in good prognosis group,the differences were statistically significant(t=3.461,3.801,6.326;all P<0.05).The ROC curve analysis results showed that the AUC of serum PCT,hs-CRP,and IL-17 for predicting the prognosis of COPD complicated with lower respiratory tract infection was 0.841(95%CI:0.733-0.919),0.740(95%CI:0.619-0.839),and 0.870(95%CI:0.766-0.939),respectively.The combined AUC of the three was 0.959(95%CI:0.881-0.992),and the AUC value of the combined indicator diagnosis was higher than that of the single indicator diagnosis(all P<0.05).Conclusion The serum levels of PCT,hs-CRP,and IL-17 were relatively high in elderly COPD patients with lower respiratory tract infections,and the combination of these indicators had certain auxiliary reference value for disease diagnosis and prognosis judgment.
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