The impact of the interaction between family history of hypertension and high uric acid on the prevalence of metabolic syndrome
Objective To understand the interaction between family history of hypertension and high uric acid on metabolic syndrome(MS),and provide reference for the prevention and treatment of MS.Methods Use 1∶2 matched case-control study,840 patients diagnosed with MS were selected as a case group based on physical examination and laboratory testing information from employees of a petrochemical enterprise who participated in occupational health examination at the physical examination center of the Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine from January to December 2022.1 680 non-metabolic syndrome people with the same sex and age(±3 years)who participated in the health examination during the same period were selected as the control group.The SPSS 25.0 software was used for c2 test and logistic regression analysis.Multiplicative and additive models were used to evaluate the interaction of family history of hypertension and high uric acid on the incidence of MS.Results Obesity,family history of hypertension,family history of diabetes,and hyperuric acid between case group and control group showed statistically significant differences(c2=315.314,9.502,7.920,80.730;all P<0.05).After adjusting for confounding factors,multivariate logistic regression analysis showed that family history of hypertension was not associated with MS,high uric acid(OR=2.059,95%CI:1.639-2.588)were associated with the high risk of metabolic syndrome,the difference was statistical significance(P<0.05).Interaction analysis showed that family history of hypertension and high uric acid had a multiplicative interaction on the incidence of MS(OR=2.129,95%CI:1.275-3.555,P<0.05).At the same time,they also had additive interaction,and the evaluation indexes such as the relative excess risk due to interaction(RERI),the atributable proportion due to interaction(AR)and the synergy index(S)of additive interaction were 1.407(95%CI:0.223-2.591),0.381(95%CI:0.160-0.603),2.102(95%CI:1.210-3.650).Conclusion Both family history of hypertension and high uric acid interact with each other to increase the risk of developing metabolic syndrome.
Family history of hypertensionHigh uric acidMetabolic syndromeInteraction effect
NETL
NSTL
万方数据
