Analysis and clinical significance of routine blood parameters of influenza A virus infection in children of different ages
Objective To investigate the differences of blood routine parameters,neutrophil/lymphocyte ratio(NLR)of children infected with influenza A virus among different age groups in Guangzhou,China,which would provide reference for early diagnosis and prevention against influenza.Methods From April 2023 to November 2023 in Panyu Sixth People's Hospital of Guangzhou,a total of 704 children aged under 14 years old with flu symptoms were enrolled in this study.According to the results of antigen test of influenza A,patients were divided into positive group(n=192)and negative group(n=512).The blood routine parameters and NLR of children＜7 years old group(n=208)and 7-14 years old group(n=496)were statistically analyzed,and the differences of blood routine parameters and NLR of children with positive result were compared between the two age groups.Results Among the 704 cases,192 children were positive with influenza A antigen,overall positive rate was 27.27％.No statistical difference was observed among gender of children with positive results(x2=2.823,P=0.093),while the positive rate of influenza A in 7～14 years old group(29.84％)was statistically higher than＜7 years old group(21.15％);the difference was statistically significant(x2=5.573,P=0.018).The lymphocyte count,lymphocyte ratio and white blood cell count in positive group of influenza A antigen in＜7 years old were significantly lower than negative group,and the NLR was significantly higher than that of negative group;the differences were significant(Z=-4.446,-2.437,-2.395,-2.379;all P＜0.05).The lymphocyte count,lymphocyte ratio and neutrophil ratio in positive group of influenza A antigen in 7-14 years old were significantly lower than those of negative group,and the NLR was significantly higher than that of negative group;the differences were significant(Z=-7.564,-6.149,-4.938,-5.892;all P＜0.05).The lymphocyte count and lymphocyte ratio in children with positive result of influenza A antigen in 7-14 years old group were significantly lower than those in＜7 years old group,and the neutrophil ratio and NLR were significantly higher than those in＜7 years old group;the differences were significant(Z=-2.529,-2.634,-2.426,-2.603;all P＜0.05).Conclusions There were differences in the routine blood parameters of children infected with influenza A virus in different age groups.Combining routine blood parameters with NLR and other indicators could provide references and indications for influenza A virus infection and diagnosis in children.
Influenza A virusBlood routine testNeutrophils/lymphocyte ratio
NETL
NSTL
万方数据
