Changes and predictive value of serum MMP-9,IL-17a and NGAL levels in patients with COPD and pulmonary infection
Objectives To explore the changes and predictive value of serum matrix metalloproteinase-9(MMP-9),interleukin-17a(IL-17a)and neutrophil gelatinase-associated lipocalin(NGAL)levels in patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.To provide reference for clinical treatment of COPD complicated with pulmonary infection.Methods A total of 140 COPD patients treated in the Respiratory Department of the Shijiazhuang Third Hospital were enrolled from September 2016 to September 2020.According to presence or absence of pulmonary infection,they were divided into infection group(n=53)and non-infection group(n=87).The levels of MMP-9,IL-17a and NGAL were compared between the two groups.The predictive values of serum MMP-9,IL-17a and NGAL levels single index and combined detection in COPD combined with pulmonary infection were evaluated by receiver operating characteristic(ROC)curve.Results A total of 62 strains of pathogenic bacteria were detected in 53 COPD patients with pulmonary infection,and the main pathogen was Gram-negative bacteria(40.32％).The serum levels of MMP-9,IL-17a and NGAL in the infected group were(243.27±30.06)μg/L,(316.37±37.72)ng/L and(40.42±6.83)ng/mL,respectively,which were higher than those in the non-infected group[(132.83±21.13)pg/L,(163.53±19.14)ng/L,(25.27±3.02)ng/mL];the differences were statistically significant(t=25.481,31.725,5.025;all P＜0.05).The results of ROC curves analysis showed that area under curve(AUC)of MMP-9 combined with IL-17a and NGAL in the diagnosis of pulmonary infection was 0.829,greater than that of MMP-9,IL-17a,NGAL single index(0.714,0.679,0.730);the differences were statistically significant(Z=2.563,2.968,2.421;all P＜0.05).Conclusion The levels of MMP-9,IL-17a and NGAL increased in patients with COPD and pulmonary infection,and their combined detection had certain predictive value for COPD combined with pulmonary infection.
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