Changes and significance of tissue p53,EGFR and inflammatory factors in postoperative infection of lung cancer
Objective To study the changes and significance of tissue p53,epidermal growth factor receptor(EGFR)and inflammatory factors in postoperative infection of lung cancer,to provide ideas for future clinical prevention of postoperative infection.Methods A total of 80 patients with lung cancer treated in the Huoshan County Hospital from February 2020 to September 2022 were selected for the study,all received surgical treatment.According to the incidence of postoperative infection,the patients were divided into infected group(n=21)and uninfected group(n=59).The positive rates of p53,EGFR and the levels of procalcitonin(PCT),interleukin-6(IL-6)and C-reactive protein(CRP)in the two groups were compared.The changes of tissue p53,EGFR and inflammatory factors and their correlation were analyzed.Results The positive rates of p53 and EGFR in the infected group(42.86％,57.14％)were significantly higher than those in the uninfected group(18.64％,5.08％);the differences were statistically significant(x2=4.843,27.551;both P＜0.05).The levels of PCT,IL-6 and CRP in the infection group were(0.47±0.12)ng/mL,(85.33±22.05)pg/mL,(115.17±26.41)mg/mL,which were significantly higher than those in the uninfected group[(0.25±0.06)ng/mL,(13.24±2.75)pg/mL,(28.69±4.12)mg/mL];the differences were statistically significant(t=10.849,24.855,24.596;all P＜0.05).Multivariate unconditional logistic analysis showed that the increased levels of p53,EGFR,PCT,IL-6 and CRP were independent risk factors for postoperative infection in patients with lung cancer;the differences were statistically significant(all P＜0.05).Correlation analysis results showed that p53,EGFR were positively correlated with PCT,IL-6 and CRP(r=0.511,0.423,0.468;0.495,0.408,0.515;all P＜0.05).Conclusion The levels of p53,EGFR and inflammatory factors were all increased in patients with postoperative infection of lung cancer,which might be the risk factors for postoperative infection of lung cancer.
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