Study on expression and correlation of Survivin,EGFR and Her2 in breast cancer
Objective To detect the expression levels of Survivin,epidermal growth factor receptor(EGFR),and human epidermal growth factor receptor 2(Her2)in breast cancer tissues,and explore the correlation between the expression of the three and its clinical pathological parameters.Methods The clinical and pathological data of 76 female breast cancer patients diagnosed pathologically at the Huizhou Central People's Hospital from January 2017 to December 2022 were collected,including age,menopausal status,pathological classification,histological grade,tumor node metastasis(TNM)stage,and size of cancer lesion etc.Immunohistochemistry was used to detect the expression levels of Survivin,EGFR and Her2 in breast cancer tissues and adjacent tissues;Spearman rank correlation was used to analyze the correlation of Survivin,EGFR and Her2 expression in breast cancer tissues;Chi-square test was used to analyze Survivin,EGFR and Her2 relationship between expression and clinicopathological parameters of breast cancer.Results The positive expression rates of Survivin,EGFR and Her2 in breast cancer tissue were 59.21％,39.47％and 52.63％,respectively,which were higher than those in adjacent cancer tissues(6.58％,9.21％and 0.00％),and the differences were statistically significant(x2=47.686,18.897,54.286;all P＜0.05).The expressions of Survivin and EGFR,Survivin and Her2,and EGFR and Her2 in breast cancer tissues were significantly positively correlated(r=0.506,0.660,0.550;all P＜0.05).There were no statistically significant differences in the expression of Survivin,EGFR and Her2 in cancer tissues of patients with different ages,menopausal status and TNM stages(x2=0.378,1.844,0.378;0.707,0.034,0.707;1.973,0.059,1.839;all P＞0.05).The differences of Survivin,EGFR and Her2 expression levels in cancer tissues of patients with different pathological types,size of cancer lesion,histological grade and lymph node metastasis status were all statistically significant(x2=34.200,27.306,31.901,24.945;12.944,15.797,7.165,21.170;15.271,35.496,25.451,36.067;all P＜0.05).Conclusions The expression levels of Survivin,EGFR and Her2 in breast cancer tissues were significantly increased,and there was a positive correlation between the three.Survivin,EGFR and Her2 were highly expressed in invasive cancer,cancer lesions＞2 cm,histological grade Ⅲ,and positive lymph node metastasis.
Breast cancerSurvivinEpidermal growth factor receptorHuman epidermal growth factor receptor 2
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