The predictive value of serum VS-2 and CTRP9 levels on heart failure after PCI in patients with acute myocardial infarction
Objective Through long-term follow-up and biomarker detection in patients with acute myocardial infarction(AMI),the relationship between serum levels of vascular suppressor factor(VS-2),C1q/tumor necrosis factor-related protein 9(CTRP9)and heart failure(HF)after percutaneous coronary intervention(PCI)was explored to evaluate its potential value in clinical prediction.Methods A total of 96 patients with AMI who underwent PCI in Hubei Jianghan Oilfield General Hospital from January 2019 to January 2022 were selected as the study subjects.After 1 year of follow-up,27 patients had HF(HF group)and 69 patients had no HF(non-HF group).The clinical data of patients were collected,and the levels of serum VS-2 and CTRP9 were detected by enzyme-linked immunosorbent assay.Multivariate logistic regression analysis was used to analyze the independent influencing factors of HF after PCI in AMI patients,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of VS-2 and CTRP9 for HF after PCI in AMI patients.Results The serum VS-2 and CTRP9 levels in the HF group[(16.83±4.22)pg/L,(9.25±2.49)ng/mL]were lower than those in the non-HF group[(25.06±6.68)pg/L,(12.62±3.03)ng/mL];the differences were statistically significant(t=5.944,5.136,both P＜0.01).Multiple logistic regression analysis showed that VS-2 and CTRP9 were independent influencing factors of HF after PCI in AMI patients,and the differences were statistically significant(OR=2.462,1.388;both P＜0.01).ROC curve analysis showed that the areas under the curve of VS-2,CTRP9 and their combination in predicting HF after PCI in AMI patients were 0.816,0.784 and 0.883,respectively,with the combination of the two having the highest predictive value.Conclusions Reduced serum VS-2 and CTRP9 levels were related to the occurrence of HF.Joint detection of these two biomarkers could more accurately predict the risk of HF in AMI patients after PCI.
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