Risk factors related to postoperative incision infection in patients with gallstones and acute cholecystitis and their association with Th1/Th2 cytokine levels
Objective To explore the risk factors for surgical incision infection in patients with gallstones and acute cholecystitis,and analyze the relationship between infection and peripheral blood T lymphocyte subsets and Thl/Th2 related cytokine levels.Methods A total of 260 patients with acute cholecystitis in Chengdu Changjiang Hospital from June 2021 to June 2023 were selected as study subjects,and they were divided into infected group(n=27)group and uninfected group(n=233)according to whether the incision infection occurred.Risk factors for postoperative incision infection were retrospective analyzed from the collection of preoperative clinical information from surgery for gallstones with acute cholecystitis patients in the hospital electronic medical record system.The changes in T lymphocyte subsets ratio and Th l/Th2 related cytokine[interleukin-2(IL-2),interferon-γ(IFN-γ),IL-4,IL-10]levels within 24 hours after surgery between two groups of patients were compared.Results The independent risk factors of surgical incision infection of cholecystolithiasis with acute cholecystitis were age ≥60 years,operation time＞60 min,diabetes,conversion to laparotomy,and no use of antibiotics before operation(all P＜0.05).The levels of CD4+/CD8+and CD4+/CD25+in the infected group were lower than those in the uninfected group(P＜0.05);IL-2 and IFN-γ levels in infected patients were lower than those of the uninfected group(P＜0.05);the levels of IL-4 and IL-10 were higher than those of the uninfected group(t=5.866,34.572,9.643,10.991,7.726,8.910;all P＜0.05).Conclusions There were many risk factors for surgical incision infection in patients with gallstones and acute cholecystitis.Targeted intervention measures could be taken clinically to reduce the incidence of infection,and infected patients might have Th cell subsets imbalance and cytokine imbalance after surgery.
Gallbladder stones with acute cholecystitis surgeryIncision infectionT lymphocyte subpopulation
NETL
NSTL
万方数据
