Clinical characteristics of patients with severe liver disease complicated with infection and predictive value of NLR and MLR
Objective To study the clinical characteristics of patients with severe liver disease complicated with infection and predictive value of neutrophil/lymphocyte ratio(NLR)and monocyte/lymphocyte ratio(MLR).Methods A total of 120 patients with severe liver disease admitted to Huangpi District People's Hospital from January 2018 to December 2022 were selected and divided into infected group(n=31)and uninfected group(n=89).The distribution of infection sites in the infected group was observed,and the NLR and MLR of the infected and uninfected groups were compared.Multivariate logistic analysis was used to analyze the risk factors of severe liver disease co-infection,and receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of NLR and MLR for severe liver disease co-infection.Results The infection sites in the infection group were mainly abdominal infection and respiratory system infection,accounting for 35.48％(11/31)and 25.81％(8/31);the NLR and MLR of the infected group were(3.55±0.38)and(0.45±0.07),respectively,which were significantly higher than those of the uninfected group(2.53±0.35),(0.31±0.05),the differences were statistically significant(t=13.667,12.037;all P＜0.001).The multivariate logistic regression analysis showed that age,Child-Pugh grade,diabetes mellitus,anemia,length of hospital stay,number of invasive operations,catheterization time were all risk factors for severe liver disease combined with infection(all P＜0.05);ROC curve analysis showed that the area under the cure(AUC)of the combined detection of NLR and MLR was 0.995 and 95％CI was 0.987-1.000,which were significantly higher than that of NLR(AUC=0.982,95％CI:0.963-1.000)and MLR(AUC=0.944,95％CI:0.885-0.980).Conclusions The infection site characteristics of patients with severe liver disease combined with infection were mainly abdominal infection and respiratory system infection,and there were many risk factors of infection in patients.Combined detection of NLR and MLR had high predictive value,and should be paid close attention to clinically.
Severe liver diseaseNeutrophil/lymphocyte ratioMonocyte/lymphocyte ratio
NETL
NSTL
万方数据
