Predictive value of systemic immune-inflammatory index for pulmonary infection in children with bronchial asthma
Objective To discuss the predictive value of systemic immune-inflammatory index(SII)for pulmonary infection in children with bronchial asthma.Methods This study included 120 children with bronchial asthma who were admitted to the Tangshan Maternal and Child Health Hospital from September 2021 to September 2023.The children were divided into pulmonary infection group(n=51)and non-pulmonary infection group(n=69)based on the presence or absence of pulmonary infection.Comparison between groups was made on clinical data,serum procalcitonin(PCT),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)levels,neutrophil to lymphocyte ratio(NLR),white blood cell count(WBC),and SII.Multivariate logistic regression analysis was performed to screen the risk factors for pulmonary infection in children with bronchial asthma.The predictive value of SII for pulmonary infection in children with bronchial asthma was evaluated using the receiver operating characteristic(ROC)curve.Results In the pulmonary infection group,CRP,TNF-α,NLR and SII were(43.56±10.17)mg/L,(2.79±0.36)ng/L,(6.52±1.44)and(1 485.09±37.63),respectively.It was significantly higher than that in the group without pulmonary infection(3.75±1.01)mg/L,(1.82±0.27)ng/L,(3.15±0.48),(815.92±30.44),all the differences were statistically significant(t=32.340,16.872,18.146,107.610;all P＜0.05).ROC curve analysis showed that the sensitivity and specificity of SII for predicting pulmonary infection in children with bronchial asthma were 88.00％and 80.00％,respectively.The area under the curve(AUC)was 0.874(95％CI:0.749-0.951).Conclusion SII was helpful for predicting pulmonary infection in children with bronchial asthma.
Bronchial asthmaPulmonary infectionSystemic immune-inflammatory index
NETL
NSTL
万方数据
