Changes in serum CA125,CYFRA21-1 and MMP-9 levels before and after chemotherapy in NSCLC patients and their clinical significance
Objective To assess the association between serum concentrations of cancer antigen 125(CA125),cytokeratin 19 fragment antigen 21-1(CYFRA21-1),matrix metallo-proteinase-9(MMP-9),and the effectiveness of chemotherapy and pulmonary infection in patients with non-small cell lung cancer(NSCLC)both before and during treatment.Methods A total of 80 patients with NSCLC who were treated in the Oncology Department of Mengcheng county the First People's Hospital from November 2019 to March 2024 were selected as the study subjects.All patients received routine examination after admission and were given cisplatin+paclitaxel chemotherapy regimen after relevant conjunctions were excluded.After 4 cycles of chemotherapy,they were divided into complete response(CR)group(n=0),partial response(PR)group(n=27),stable disease(SD)group(n=34),and disease progression(PD)group(n=19)according to clinical efficacy.The expression levels of serum CA125,CYFRA21-1 and MMP-9 were measured in peripheral blood of all patients before and after chemotherapy.Peripheral blood of all patients was collected before and after chemotherapy.The predictive value of CA125,CYFRA21-1,and MMP-9 for pulmonary infection following chemotherapy in NSCLC was determined using a receiver operating characteristic(ROC)curve.Results After chemotherapy,serum CA125,CYFRA21-1 and MMP-9 levels were significantly lower than those before chemotherapy,the differences were statistically significant(t=6.993,9.458,6.818;all P＜0.001).CA125,CYFRA21-1 and MMP-9 after chemotherapy in partial response(PR)and stable disease(SD)groups were significantly decreased compared with those before chemotherapy(tPR group=3.010,17.52,3.219,all P＜0.05;tSD group=9.689,10.879,6.411,all P＜0.001).In progressive disease(PD)group,CYFRA21-1 after chemotherapy was significantly lower than that before chemotherapy(t=12.990,P＜0.001).Among all the 80 patients,the serum levels of CA125,CYFRA21-1 and MMP-9 in the infected group were significantly higher than those in the non-infected group(t=4.106,6.543,5.128;all P＜0.001).ROC curve indicated that the sensitivities of CA125,CYFRA21-1 and MMP-9 in predicting pulmonary infection after chemotherapy in NSCLC patients were 72.5％,77.6％and 69.7％,respectively;the specificities were 79.9％,76.3％and 73.9％,respectively,and the area under the curve(AUC)values were 0.843,0.846 and 0.864,respectively.Upon combining the three indexes,the sensitivity was determined to be 81.6％,the specificity was found to be 72.2％,and the AUC was calculated to be 0.920.Conclusions There exists a substantial association between the levels of CA125,CYFRA21-1,and MMP-9 and the efficacy of chemotherapy as well as the occurrence of pulmonary infection in patients with NSCLC.Furthermore,these levels possess considerable predictive value in relation to pulmonary infection following chemotherapy.
Non-small cell lung cancerCancer antigenl25Cytokeratin 19 fragment antigen 21-1Matrix metallo-proteinase-9
NETL
NSTL
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