Analysis of risk factors of anesthesia-related infection and changes of oxidative stress level in elderly patients undergoing general anesthesia during perioperative period
Objective To investigate the risk factors of anesthesia related infection in elderly patients undergoing general anesthesia during perioperative period and the predictive value of oxidative stress index.Methods A total of 90 patients with perioperative infection after surgery under general anesthesia treated in the First People's Hospital of Mengcheng from July 2020 to December 2022 were selected as the infection group.218 patients in the same age group with informed consent and no perioperative infection were selected as the non-infected group.The medical records of the enrolled subjects were registered and recorded by specially-assigned persons,and then the risk factors of infection were analyzed.Serum levels of superoxide dismutase(SOD),malondialdehyde(MDA)and catalase(CAT)in the two groups were detected before surgery,1 day before fever appeared in the infected group,and 2 days after surgery in the uninfected group.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of the above indexes for perioperative anesthesia-related infections in elderly patients undergoing general anesthesia.Results There was a statistical difference in the number of cases of trachea,deep vein artery puncture,diabetes and sodium lime replacement between infected and uninfected patients(x2=15.758,4.250,6.122,11.590;all P＜0.05).The results of multifactor analysis showed that the influencing factors of anesthesia related infection in elderly patients undergoing general anesthesia surgery during the perioperative period were that the trachea was endotracheal tube,deep vein artery puncture was performed,diabetes was complicated,and the number of sodium lime replacement was less than 1 time/day(all P＜0.05).There was no significant difference in preoperative SOD,MDA and CAT levels between the two groups(P＞0.05);postoperative SOD and CAT levels in the infected group were lower than those in the uninfected group(t=1 1.748,9.346;all P＜0.001),while MDA levels were higher than those in the uninfected group(t=5.234,P＜0.001).ROC curve analysis results showed that serum SOD(AUC=0.866,95％CI:0.825-0.907,critical value:22.37 U/L),MDA(AUC=0.666,95％CI:0.597-0.736,critical value:54.29 U/L),CAT(AUC=0.811,95％CI:0.763-0.860,critical value:34.79 U/L)had a certain predictive value for perioperative anesthesia-related infection in elderly patients undergoing general anesthesia.Conclusion There were relatively more risk factors of anesthesia-related infection in elderly patients undergoing general anesthesia during perioperative period,and the changes of serum SOD,MDA and CAT levels had certain predictive value for their infection.
Anesthesia related infectionSuperoxide dismutaseMalondialdehydeCatalase
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