Association between DDX58 gene polymorphism and chronic HBV infection
Objective DExD/H-box helicase 58(DDX58)plays an important role in human innate immunity and may affect the prognosis of hepatitis B virus(HBV)infection.The aim of this study was to investigate the association of single nucleotide polymorphic sites(SNPs)in the RIG-Ⅰ gene with HBV infection chronicity.Methods A total of 48 417 people from 20 villages in Zhangjiagang were selected for health examination and regular follow-up from September 2009 to March 2010.A total of 842 baseline hepatitis B surface antigen(HBsAg)positive patients were included in this study in November 2020;674 were asymptomatic and 168 were chronic hepatitis B(CHB).Two SNPs(DDX58 rs9695310,rs10738889)were genotyped to explore their relationship with HBV infection chronicity.t-test,x2-test and multivariate logistic regression were applied to analyze the relationship of these SNPs with HBV infection chronicity.Results rs9695310 gene polymorphism was associated with HBV infection chronicity(P=0.004).Compared with asymptomatic carriers,patients carrying the mutated allele rs9695310-C were more likely to become chronic(dominant model:OR=1.74,95％CI:1.18-2.54).Mutations in the rs9695310 gene were risk factors for chronic HBV infection;rs9695310,gender,age,platelets,A/G,and total cholesterol were independent predictors of HBV infection chronicity.The ROC curve analysis showed the above six independent factors could effectively distinguish chronic HBV infection from asymptomatic infection(AUC=0.738).Conclusion DDX58 rs9695310 was associated with chronic HBV infection in Chinese Han population and could serve as a predictive indicator for the outcome of HBV infection.
NETL
NSTL
万方数据
