Relationship between serum PCT,sTREM-1,S100A9 level and cardiac function and prognosis in elderly patients with heart failure combined with pulmonary infection
Objective To explore the relationship between serum procalcitonin(PCT),soluble triggering receptor expressed on myeloid cells-1(sTREM-1),S100 calcium-binding protein A9(S100A9)and cardiac function and prognosis in elderly patients with heart failure(HF)combined with pulmonary infection.Methods A total of 171 elderly patients with HF combined with pulmonary infection who were admitted to the Qinghai University Affiliated Hospital from January 2020 to January 2022 were selected as infection group,and 106 patients with HF without infection during the same period were randomly selected as non-infection group.Infection group was divided into poor prognosis group(36 cases)and good prognosis group(135 cases)based on the prognosis.The serum PCT,sTREM-1 and S100A9 levels,left ventricular ejection fraction(LVEF),QRS complex duration(QRSd),and LVEF/QRSd ratio were compared between infection group and non-infection group,as well as between good prognosis group and poor prognosis group.The correlation between PCT,sTREM-1,S100A9 and LVEF,QRSd and LVEF/QRSd were analyzed;the risk factors of poor prognosis in elderly patients with HF combined with pulmonary infection were analyzed by univariate and multivariate logistic regression,and the predictive value of serum PCT,sTREM-1,S100A9,and their combined detection for predicted poor prognosis in elderly patients with HF combined with pulmonary infection was analyzed by the receiver operating characteristic(ROC)curve.Results The levels of serum PCT,sTREM-1,S100A9,and QRSd in infection group,poor prognosis group were significantly higher than those in non-infection group,good prognosis group,the differences were statistically significant(t=-27.483,-19.304,-25.813,-9.103,t=-8.328,-8.258,-8.675,-10.490;all P＜0.05),and the LVEF and LVEF/QRSd ratio were significantly lower than those in non-infection group,poor prognosis group,the differences were statistically significant(t=17.908,19.414,t=10.479,15.112;all P＜0.05).There was a positive correlation between serum PCT,sTREM-1,S100A9 and QRSd in elderly patients with HF combined with pulmonary infection(r=0.622,0.633,0.626;all P＜0.05),and there was a negative correlation between them and LVEF and LVEF/QRSd ratio(rLVEF=-0.617,-0.604,-0.648,rLVEF/QRSd=-0.655,-0.665,-0.692;all P＜0.05).Multivariate logistic regression analysis showed that serum PCT,sTREM-1,S100A9,B-type natriuretic peptide(BNP),LVEF/QRSd ratio,and the American New York Heart Assocication(NYHA)cardiac function grade Ⅲ-Ⅳ were influencing factors of prognosis in elderly patients with HF combined with pulmonary infection(all P＜0.05).The area under the curve(AUC)of serum PCT,sTREM-1,S100A9,and their combined detection for predicted poor prognosis in elderly patients with HF combined with pulmonary infection were 0.847,0.839,0.863,and 0.969,respectively.Conclusions Serum PCT,sTREM-1,and S100A9 were closely correlated with cardiac function and prognosis in elderly patients with HF and pulmonary infection.Early detection of serum PCT,sTREM-1,and S100A9 levels had a high predictive value for the prognosis of elderly patients with HF and pulmonary infection.
Heart failurePulmonary infectionProcalcitoninSoluble triggering receptor expressed on myeloid cells-1S100 calcium-binding protein A9
万方数据
维普
