Clinical value of serum GH and AGR2 levels in predicting postoperative recurrence in patients with functional pituitary adenoma
Objective To analyze the predictive value of serum growth hormone(GH)and anterior gradient-2(AGR2)levels on postoperative recurrence in patients with functional pituitary adenoma.Methods From March 2021 to March 2023,191 patients with functional pituitary adenoma treated in our hospital were selected and divided into recurrent group(38 cases)and non-recurrent group(153 cases).The serum GH and AGR2 levels of the two groups were compared.The correlation between serum GH and AGR2 levels in the recurrent group was analyzed using Pearson analysis,and the factors affecting the prognosis of patients with functional pituitary adenoma were analyzed using logistic regression analysis;the prognostic value of serum GH and AGR2 levels in patients with functional pituitary adenoma was evaluated using receiver operating characteristic(ROC)analysis.Results The serum GH and AGR2 levels in the recurrent group were significantly higher than those in the non-recurrent group,the differences were statistically significant(t=7.316,7.233;all P＜0.05).There was a positive correlation between serum GH and serum AGR2 in the recurrent group(r=0.449,P=0.005).There was an obvious difference in tumor staging between the recurrent group and the non-recurrent group,the difference was statistically significant(x2=4.261,P＜0.05).The proportion of tumor staging stages Ⅲ-Ⅳ in the recurrent group was higher than that in the non-recurrent group,while the proportion of stages Ⅰ-Ⅱ was lower than that in the non-recurrent group.Tumor staging,serum GH level,and serum AGR2 level were related factors affecting the prognosis of patients with functional pituitary adenoma(OR=2.736,1.827,1.925,P＜0.05).The sensitivity of serum GH in predicting the prognosis of patients with functional pituitary adenoma was 76.32％,and the area under the curve(AUC)was 0.845(95％CI:0.776-0.913);the sensitivity of serum AGR2 level in predicting the prognosis of patients with functional pituitary adenoma was 78.95％,and the AUC was 0.843(95％CI:0.774-0.912),the sensitivity and AUC of serum GH level combined with serum AGR2 level in predicting the prognosis of functional pituitary adenoma patients was relatively high,with values of 92.11％and 0.938(95％CI:0.903-0.973),respectively;the predictive value of serum GH combined with serum AGR2 for the prognosis of patients with functional pituitary adenoma was better than that of single factor alone(Zcombination vs.GH=3.200,P=0.001;Zcombination vs.AGR2=3.1 14,P=0.002).Conclusions Elevated serum GH and AGR2 levels in patients with functional pituitary adenoma were not conducive to their prognosis.The combination of the two could provide some reference for predicting postoperative recurrence in patients with functional pituitary adenoma.
万方数据
维普
