The expression and clinical significance of miR-126 and Th1 related cytokines in the serum of non-small cell lung cancer patients
Objective To investigate the expression levels of miR-126 and Th1 related cytokines in the serum of non-small cell lung cancer(NSCLC)patients and their relationship with tumor marker levels and clinical pathological characteristics.Methods A total of 102 NSCLC patients admitted to the Zigong First People's Hospital from April 2020 to March 2023 were selected as the study group,and 102 health examination people during the same period were selected as the control group.The levels of miR-126,Th1 related cytokines[interleukin(IL)-2,interferon(IFN)-γ,tumor necrosis factor(TNF)-α],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA125,cytokeratin 19 soluble fragment(CYFRA)]of the two groups were detected and compared.Study group patients'TNM staging,lymph node metastasis,and other clinical and pathological characteristics were statistically analyzed.The levels of miR-126,Th1 related cytokines,and tumor markers in NSCLC patients with different clinical and pathological characteristics were compared.Pearson correlation method was used to analyze the relationship between miR-126,Th1 related cytokines with tumor marker levels in NSCLC patients.Results The levels of serum miR-126 and IL-2 in the study group were significantly lower than those in the control group(t=15.816,81.256),while the levels of serum IFN-γ,TNF-α,CEA,CA199,CA125 and CYFRA were significantly higher than those in the control group(t=39.166,30.190,62.488,24.722,58.627,27.539),the differences were statistically significant(all P＜0.05).The levels of serum miR-126 and IL-2 in patients with TNM stageⅢ and Ⅳ were significantly lower than those in patients with TNM stage Ⅰ and Ⅱ(t=6.060,5.509),while the levels of serum IFN-γ,TNF-α,CEA,CA199,CA125 and CYFRA were significantly higher than those in patients with TNM stageⅠ and Ⅱ(t=10.944,8.196,11.027,11.603,10.384,7.566),the differences were statistically significant(all P＜0.05).The levels of serum IFN-γ,TNF-α,CEA,CA125 and CYFRA in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,the differences were statistically significant(t=8.951,6.414,8.852,8.690,7.224;all P＜0.05).Pearson correlation analysis showed that the levels of serum miR-126,IL-2,IFN-γ and TNF-α in NSCLC patients were closely related to the levels of serum CEA,CA199,CA125 and CYFRA(P＜0.05).Conclusion The levels of miR-126 and Th1 related cytokines in NSCLC patients were correlated with tumor marker levels and clinical pathological characteristics,which might serve as reference indicators for the disease severity diagnosis of NSCLC.
miR-126Th1 related cytokinesNon-small cell lung cancerTumor markersClinical pathological features
万方数据
维普
