Clinical value of serum PCT,IL-6,hs-CRP and IgE level in children with bronchopneumonia
Objective To explore the changes of serum levels of procalcitonin(PCT),interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP),and immunoglobulin E(IgE)in children with bronchopneumonia,and the diagnostic value of their combination.Methods A total of 95 pediatric patients with infectious bronchopneumonia were selected as observation group from October 2020 to October 2022.Additionally,100 healthy children who underwent physical examinations in the Pediatric Outpatient Department of the hospital were selected as control group.Observation group was further divided into virus group(n=53),bacteria group(n=42);general group(n=58)and severe group(n=37).Serum levels of PCT,IL-6,hs-CRP,and IgE levels were determined in all research subjects and compared their changes in different groups;their diagnostic value for pediatric bronchopneumonia were analyzed using receiver operating characteristic(ROC)curves.Results The levels of PCT,IL-6,hs-CRP,and IgE in the serums of observation group were all significantly higher than those in the control group(t=15.336,25.085,33.598,27.218;all P＜0.05).The ROC curve analysis results showed that the area under the curve(AUC)values of serum PCT,IL-6,hs-CRP,IgE and joint index were 0.698(95％CI:0.611-0.785),0.777(95％CI:0.701-0.854),0.737(95％CI:0.655-0.820),0.678(95％CI:0.592-0.764),and 0.872(95％CI:0.814-0.929),respectively,with single factor AUC values lower than the joint prediction probability(P＜0.05).The serum PCT,IL-6,and hs-CRP levels in the virus group were significantly lower than those in the bacterial group(t=18.967,13.145,31.697;all P＜0.05).The serum levels of PCT,IL-6,hs-CRP,and IgE in the general group were significantly lower than those in the severe group(t=14.231,16.538,18.078,13.796;all P＜0.05).Conclusion The combination of serum PCT,IL-6,hs-CRP,and IgE detection results could assist in the diagnosis of pediatric bronchopneumonia,and reflect the changes in the condition to a certain extent.
BronchopneumoniaPCTInterleukin-6High sensitivity C-reactive proteinImmunoglobulin E
万方数据
维普
