The value of lipid indicators combined with AFP in the diagnosis of chronic hepatitis B-related hepatocellular carcinoma
Objective To investigate the diagnostic value of serum alpha-fetoprotein(AFP)combined with lipid indicators in chronic hepatitis B-related hepatocellular carcinoma(HCC).Methods A total of 1 045 patients with hepatitis B virus(HBV)infection admitted to the Third Affiliated Hospital of Sun Yat-sen University from January 2012 to September 2018 were selected,including 724 patients with HBV non-HCC and 321 patients with HBV-related HCC.Univariate analysis and multivariate logistic regression analysis were used to screen variables to construct a logistic regression model for chronic hepatitis B-related HCC.The area under the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of the model.Results There were statistically significant differences in sex,AFP,age,triglyceride and low-density lipoprotein cholesterol between the HBV-related HCC group and the HBV non-HCC group(x2/Z=16.651,253.415,-11.183,-3.309,-4.155;all P＜0.05).Multivariate logistic regression analysis showed that male,age,AFP 20-＜400 ng/mL,AFP 400-ng/mL,and low-density lipoprotein cholesterol were independent risk factors for HBV-related HCC(OR=4.886,1.081,4.101,34.604,1.518;all P＜0.00 1),while triglyceride was a protective factor(OR=0.413,P＜0.001).The area under the ROC curve of the logistic regression model constructed by the above indicators and independent AFP was 0.870(sensitivity:0.773,specificity:0.815)and 0.748(sensitivity:0.698,specificity:0.713),respectively.Conclusion The logistic regression model of serum AFP combined with triglyceride and low-density lipoprotein cholesterol had a good diagnostic efficiency,which had certain clinical significance for the early diagnosis of hepatitis B-related HCC.
万方数据
维普
