Detection and clinical significance of vaginal microecology in patients with cervical intraepithelial neoplasia and high-risk HPV infection
Objective To explore vaginal microecology status and correlation in patients with cervical intraepithelial neoplasia(CIN)and high-risk human papilloma virus(HPV)infection.Methods A total of 78 patients with CIN diagnosed in Danzhou People's Hospital from March 2020 to January 2023 were enrolled.According to the results of HPV-DNA screening,they were divided into high-risk HPV infection group and non-infection group.The general data and vaginal microecology in the two groups were compared.The relationship between vaginal microecology and CIN combined with high-risk HPV infection was analyzed.Results Among the 78 CIN patients,there were 25 cases with high-risk HPV infection,mainly including type HPV16(32.00％),HPV18(20.00％)and HPV52(16.00％).The incidence of bacterial vaginosis(BV)and aerobic vaginitis(AV),abnormal rates of Lactobacillus and vaginal pH in infection group were significantly higher than those in non-infection group,the differences were statistically significant(x2=5.598,6.228,10.626,8.569,P=0.018,0.013,0.001,0.003).The vaginal pathogens were mainly on clue cells(39.74％),Candida(7.69％)and Trichomonas vaginalis(33.33％).Binary logistic regression analysis showed that Lactobacillus of types Ⅱ b and Ⅲ(OR=4.768,P=0.004)and abnormal rate of vaginal pH(OR=3.846,P=0.002)were independent risk factors of high-risk HPV infection in CIN patients.Conclusions High proportion of types Ⅱ b and Ⅲ Lactobacillus and abnormal rate of vaginal pH might be independent risk factors of high-risk HPV infection in CIN patients.Improving vaginal microecology could beneficial to reduce the risks of high-risk HPV infection and disease progression to cervical cancer.
Cervical intraepithelial neoplasiaHigh-risk human papilloma virusVaginalf microecologyLactobacillus
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