Investigation on new hepatitis B virus infection among residents in Zhangjiagang city
Objective To investigate the status of new hepatitis B virus(HBV)infection in Zhangjiagang city,Jiangsu province,and analyze the influencing factors of infection,so as to provide scientific basis for the development of hepatitis B prevention and control strategy.Methods A total of 80 613 residents who participated in the Comprehensive Prevention and Treatment of hepatitis B in Zhangjiagang city during"The eleventh Five-Year Plan"and"The twelfth Five-Year Plan"and the screening results of hepatitis B surface antigen(HBsAg)were negative were selected as the study objects,and the follow-up investigation and hepatitis B serological detection were conducted during"The thirteenth Five-Year Plan"period.Results A total of 72 149 people were followed up,the follow-up rate was 89.50％,the cumulative new infection rate of HBV was 1.72％,and the overall positive rate of anti-HBs was 44.81％.The new infection rates of HBV in males and females were 1.78％and 1.63％,respectively,and the positive rates of anti-HBs were 44.95％and 44.63％,respectively;the differences were not statistically significant(x2=2.389,0.758,P=0.122,0.384).The new infection rates of HBV in＜20,20-＜40,40-＜60,60-＜80 and 80-years old were 1.14％,1.51％,2.00％,1.73％and 1.40％,respectively,and the positive rates of anti-HBs were 14.77％,42.71％,49.60％,44.56％,40.36％,respectively,the differences were statistically significant(x2=15.378,339.340;all P＜0.001).The rate of new HBV infection in the group with a family history of hepatitis B(4.51％)was higher than that in the group without a family history of hepatitis B(1.68％),and the rate of new HBV infection in the group without hepatitis B vaccine(1.79％)was higher than that in the group with vaccination(1.18％),the differences were statistically significant(x2=49.771,12.310;all P＜0.001).Multivariate logistic regression analysis showed that 40-＜60 years old(OR=1.548,P＜0.001),family history of hepatitis B(OR=3.103,P＜0.001),and no hepatitis B vaccination(OR=1.621,P＜0.001)were independent influencing factors for new HBV infection.Conclusions The new infection rate of HBV in Zhangjiagang city was high and the overall positive rate of anti-HBs was low.Adult hepatitis B vaccination should be strengthened and HBsAg screening should be carried out actively.
Hepatitis B virusNew infectionAnti-HBsHepatitis B vaccination
万方数据
维普
