The diagnostic value of serum PAD2,PCT and CRP in sepsis
Objective To investigate the diagnostic value of serum peptidylarginine deiminase 2(PAD2),procalcitonin(PCT)and C-reactive protein(CRP)in sepsis.Methods A total of 111 sepsis patients(sepsis group)and 50 non-sepsis patients(non-sepsis group)admitted to the Intensive Care Unit of Renmin Hospital of Wuhan University from January to December 2022 were selected,and 48 healthy subjects(control group)were selected during the same period.Serum PAD2 levels were measured by ELISA,PCT levels were measured by automatic chemiluminescence immunoassay,and CRP levels were measured by automatic protein analyzer.The levels of PAD2,PCT and CRP were compared among the three groups;multivariate logistic regression analysis was used to identify the risk factors affecting sepsis;Spearman correlation test was used to analyze the correlation between PAD2 and PCT,CRP.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of PAD2,PCT and CRP for diagosis of sepsis;kappa consistency test was used to analyze the diagnostic accuracy.Results The levels of serum PAD2,PCT and CRP in the sepsis group[35.49(23.91,53.41)ng/mL,10.60(3.20,16.90)ng/mL,108.29(40.25,168.72)mg/L]were significantly higher than those in the non-sepsis group[22.52(12.89,33.64)ng/mL,2.85(1.58,4.46)ng/mL,33.99(15.38,58.09)mg/L]and the control group[9.83(7.33,15.22)ng/mL,0.04(0.04,0.06)ng/mL,3.00(3.00,3.00)mg/L](all P＜0.05);and those in the non-sepsis group were higher than those in the control group(all P＜0.05).Serum PAD2 level was positively correlated with PCT and CRP(r=0.384,0.319;both P＜0.05).Increased levels of PAD2,PCT and CRP were independent risk factors for sepsis(all P＜0.01).The area under the curve(AUC)of serum PAD2 combined with PCT and CRP for the diagnosis of sepsis was 0.955,which was higher than that of PAD2,PCT and CRP alone(0.845,0.882,0.870),respectively(Z=5.028,3.998,4.204,all P＜0.001);The Kappa of serum PAD2 combined with PCT and CRP was 0.779,which was higher than that of PAD2,PCT and CRP alone(0.521,0.611,0.576).Conclusions The levels of serum PAD2,PCT and CRP in patients with sepsis were increased,which were risk factors for sepsis.And the combination of the three had the highest diagnostic value.
SepsisPeptidylarginine deiminase 2ProcalcitoninC-reactive protein
万方数据
维普
