The effect of human immunoglobulin therapy on IL-8,TLR2,hs-CRP in neonatal infectious pneumonia
Objective To investigate the clinical symptoms and immune function improvement of neonatal infectious pneumonia treated with human immunoglobulin,and the effects on the levels of serum interleukin-8(IL-8),Toll like receptor 2(TLR2),hypersensitive C-reactive protein(hs-CRP)after treatment.Methods A total of 200 newborns who were hospitalized and diagnosed with infectious pneumonia in the Department of Newborns,Wuhan Third Hospital from October 2020 to October 2023 were selected as the study subjects.They were divided into observation group(n=100)and control group(n=100)according to the international alphabetical arrangement method.The control group received routine treatment for infectious pneumonia,while the observation group received intravenous infusion of human immunoglobulin in addition to the control group treatment plan,for a total of 5 days.The clinical symptom/sign relief and hospitalization time of two groups of children after treatment were recorded,and the adverse drug reactions during the treatment period was calculated;the levels of immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),IL-8,TLR2,hs-CRP before and after treatment were determined.Results The remission time of clinical symptoms/signs(fever reduction,disappearance of cough,relief of shortness of breath,relief of wheezing,disappearance of rales)and length of hospitalization of the observation group were significantly shorter than those of the control group(t=6.646,12.090,17.227,13.693,12.079,12.120;all P＜0.05).Before treatment,there were no significant differences in the levels of IgA,IgM,IgG,IL-8,TLR2 and hs-CRP between the two groups(all P＞0.05);after treatment,the levels of IgA,IgM and IgG in the observation group and the control group were higher than those than those before treatment(t=23.200,45.116,30.000;8.511,8.000,9.767);the levels of IL-8,TLR2 and hs-CRP were significantly lower than those before treatment(t=91.155,74.849,139.475;70.971,41.977,87.956)(all P＜0.05);the levels of IgA,IgM and IgG in the observation group were higher than those in the control group(t=12.827,24.507,12.442);the levels of IL-8,TLR2 and hs-CRP in the observation group were lower than those in the control group(t=13.536,14.795,22.010)(all P＜0.05).Both groups of children with infectious pneumonia did not experience any adverse drug reactions during treatment.Conclusion Human immunoglobulin therapy for neonatal infectious pneumonia could effectively alleviate clinical symptoms and signs,improve the body's immunity,and improve serum IL-8,TLR2,hs-CRP levels without increasing drug adverse reactions.
Neonatal infectious pneumoniaHuman immunoglobulinInterleukin-8Toll like receptor 2Hypersensitivity C-reactive protein
万方数据
