Analysis of antibiotic-resistant bacteria in 470 cases of hospitalized hepatitis B patients
Objective To analyze the types of bacteria and their drug resistance that could lead to hospital-acquired infections in patients with hepatitis B,and provide reference for clinicians in the treatment of infected patients.Method Using Excel 2019 and WHONET 5.6 software,a retrospective analysis was conducted on 470 strains of bacteria isolated from hospitalized patients with hepatitis B at the Third Affiliated Hospital of Sun Yat-sen University from January 2020 to December 2022,regarding their types and drug resistance.Results The age of the patients mainly ranged from＞50-60 years old(37.7％).The top three specimen types were sputum(26.2％),ascites(19.6％),and blood(14.5％).The top five isolated bacteria were Klebsiella pneumoniae(16.0％),Escherichia coli(14.7％),Enterococcus faecalis(8.1％),Staphylococcus aureus(5.7％),and Acinetobacter baumannii complex(5.7％).Among Gram-negative rods,the detection rates of carbapenem-resistant(Ertapenem)Klebsiella pneumoniae and Escherichia coli both exceeded 10％,while the detection rate of carbapenem-resistant(Imipenem)Acinetobacter baumannii complex reached 54.2％.Among Gram-positive cocci,Enterococcus faecalis showed high resistance rates to levofloxacin,erythromycin,and tetracycline,and the detection rate of methicillin-resistant Staphylococcus aureus reached 37.0％.Conclusions Klebsiella pneumoniae,Escherichia coli and Enterococcus faecalis were the main bacteria causing nosocomial infection in patients with hepatitis B.The detection rate of sputum,ascites and blood was high,Carbapenem-resistant strains have become a significant threat in hospital-acquired infections,which could provide reference for clinical doctors.
万方数据
维普
