The expression and correlation of serum SHBG,25(OH)D3 and P1NP in girls with idiopathic central precocious puberty
Objective To analyze the expression and correlation of serum sex hormone binding globulin(SHBG),25-hydroxyvitamin D3[25(0H)D3],and type I procollagen amino terminal extension peptide(P1NP)in girls with idiopathic central precocious puberty(ICPP),and provide evidence for early diagnosis and treatment of ICPP in girls.Methods A total of 122 ICPP girls(observation group)admitted to the Department of Pediatrics,Maternal and Child Health Hospital of Inner Mongolia Autonomous Region from November 2018 to November 2022 were selected as the research objects,and 57 normal development girls of the same age who underwent physical examination in our hospital during the same period were selected as the control group.The general clinical data of all subjects were collected.The levels of serum SHBG,25(OH)D3,P1NP,luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E2)were detected and compared between the two groups.Pearson model was used to analyze the correlation between SHBG,25(OH)D3,P1NP and sex hormone levels in ICPP girls.The receiver operating characteristic(ROC)curve was constructed to analyze the predictive value of SHBG,25(OH)D3 and P1NP for ICPP.Results The levels of SHBG and 25(OH)D3 in the observation group were lower than those in the control group,while the levels of P1NP,LH,FSH and E2 were higher than those in the control group,and the differences were statistically significant(t=8.961,9.931,11.018,15.999,12.693,13.944;all P＜0.05).Pearson model analysis showed that SHBG and 25(OH)D3 were negatively correlated with LH,FSH and E2 levels(r=-0.527,-0.534,-0.437;-0.623,-0.419,-0.324;all P＜0.05),and P1NP was positively correlated with LH,FSH and E2 levels(r=0.319,0.631,0.587;all P＜0.05).The area under curve(AUC)of ICPP predicted by combined detection of SHBG,25(OH)D3 and P1NP was 0.970,which was significantly higher than that of SHBG,25(OH)D3 and P1NP alone(0.845,0.861,0.910)(all P＜0.05).Conclusions The levels of serum SHBG and 25(OH)D3 in girls with ICPP decreased abnormally,and the levels of P1NP increased abnormally.The combined detection of serum SHBG,25(OH)D3 and P1NP levels had a high value in predicting ICPP.Paying close attention to the changes of their levels could be a better clinical diagnosis and treatment of ICPP.
SHBG25(OH)D3P1NPIdiopathic central precocious puberty
万方数据
维普
