The predictive value of FOXO1 and PLGF levels in serum for early onset preeclampsia in pregnant women in early and middle pregnancy
Objective To analyze the predictive value of forkhead box protein O1(FOXO1)and placental growth factor(PLGF)levels in serum for early onset preeclampsia in pregnant women in early and middle pregnancy.Methods A total of 180 pregnant women in early and middle pregnancy with early onset preeclampsia diagnosed in the Beijing Daxing District People's Hospital from January 2021 to June 2022 were selected as the observation group,and 185 normal pregnant women in early and middle pregnancy at the same time as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect the levels of FOXO1 and PLGF in the serum of pregnant women in early and middle pregnancy;the correlation between FOXO1 and PLGF levels in serum of pregnant women with early onset preeclampsia was analyzed by Pearson.Logistic regression analysis was used to analyze the factors influencing the occurrence of early onset preeclampsia in early and middle pregnancy;the predictive value of serum FOXO1 and PLGF levels for the occurrence of early onset preeclampsia in early and middle pregnancy was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum FOXO1 and PLGF in the observation group were significantly lower than the control group(t=18.189,17.856;both P＜0.05).There was a positive correlation between serum FOXO1 and PLGF levels in early onset preeclampsia(r=0.410,P＜0.05).Logistic regression analysis showed that FOXO1 and PLGF were protective factors for early onset preeclampsia in early and middle pregnancy(both P＜0.05).The area under the curve(AUC)of serum FOXO1 combined with PLGF for early onset preeclampsia in early and middle pregnancy was 0.953,which was better than FOXO 1 and PLGF alone(0.895,0.916);the differences were statistically significant(Z=3.074,2.151;both P＜0.05).Conclusion The levels of serum FOXO1 and PLGF in pregnant women with early onset preeclampsia decreased,which had certain predictive value for early onset preeclampsia in early and middle pregnancy.
Early and middle pregnancyFOXO1PLGFEarly onset preeclampsia
万方数据
维普
