Evaluation of HIV-infected patients'knowledge about AIDS drugs and confidence in taking medicine among those who lost follow-up to antiviral treatment
Objective To evaluate the knowledge of AIDS drugs and the confidence of taking AIDS drugs,and the influencing factors,and provide a valuable reference for reducing the loss of follow-up of HIV patients.Methods A total of 112 lost patients who received antiviral treatment in AIDS Clinical Treatment Center of Guangxi(Nanning)were selected as the lost follow-up group and 200 non-lost patients were randomly selected as the control group from January 2021 to December 2022.The National Natural Science Foundation Sino-US Cooperation Project were used to evaluate the AIDS drug-related knowledge of the lost follow-up group and the control group,including the awareness rate of drug-related knowledge and confidence(10 items)and the confidence of taking drugs on time(7 items).Gender,age,household register,place of residence,educational level,work situation,monthly family income,confidence in adverse drug reactions,no one to remind taking medicine,and knowledge related to drugs were univariate screened at the level of α=0.10,and the results of univariate analysis were incorporated into logistic regression analysis.The factors influencing the confidence of HIV-infected people to take medicine correctly were evaluated.Results There were significant differences between the two groups in age,education level,confidence in adverse drug reactions,no one to remind taking medicine,and knowledge related to drugs(x2/t=-3.714,6.327,71.548,42.814,41.179;all P＜0.05).In terms of knowledge about AIDS drugs,the average proportion of knowledge in the lost follow-up group was 51.96％,lower than 85.45％in the control group.The two groups showed significant differences in 10 items of the AIDS drug knowledge[(1)I know what to do if I miss taking the medication;(2)taking the medication correctly can reduce the viral load;(3)I know when to take the medication;(4)If I don't take my medications as prescribed,they may no longer work for me;(5)I know what kind of adverse drug reactions caused by the drugs I take;(6)I know how to deal with adverse drug reactions I may have;(7)If I occasionally skipping,my medications is not good for me:(8)Taking medicine on time can keep the drugs in the body stable;(9)Some drugs must be taken before(or after)meals to have effect;(10)Drug resistance indicated that the drug could not continue to kill the virus](x2=101.027,50.001,55.773,85.301,169.025,83.705,17.236,31.429,18.175,37.793;all P＜0.05).Among them,the item with the biggest difference was(5)I know what kind of adverse drug reactions caused by the drugs I take(70.68％).Regarding the confidence in taking medicine on time,except for item(3)It is inconvenient to take medicine in the presence of others,the average proportion of the confidence in the remaining six items in the lost follow-up group[(1)Adverse drug reactions;(2)No one reminds to take medicine;(4)Need to take multiple medicines every day;(5)Feel in good physical condition;(6)If you feel uncomfortable(cold,etc.);(7)Need to take medicine multiple times a day]was 72.32％,which was lower than 92.16％in the control group;the differences between the two groups in the six items were statistically significant(x2=71.853,43.128,28.500,14.786,21.870,6.367;all P＜0.05);the item with the largest difference was(1)Adverse drug reactions(41.21％).The five factors with statistical significance in univariate analysis were included in the multivariate logistic regression analysis.The factors that finally entered the regression model were adverse drug reactions,no one to remind taking medicine,and drug-related knowledge,the adjusted OR values and 95％CI were 6.021(1.819-8.893),1.614(1.108-2.406)and 2.493(1.125-5.137),respectively.Conclusions The awareness rate of drug-related knowledge and confidence in taking medicine among patients who were lost of follow-up in antiviral treatment were lower than those of HIV-infected patients under treatment.The factors that affected their confidence in taking medicine were adverse drug reactions,no one to remind taking medicine,and drug-related knowledge.
AIDSAntiviral treatmentAIDS drugsRelevant knowledgeConfidence in taking medicine
万方数据
维普
