Epidemiological and etiological characteristics of hand-foot-and-mouth disease in children in a single center in Xi'an during 2018-2022
Objective To investigate the epidemiological and etiological characteristics of hand-foot-and-mouth disease(HFMD)in children,and provide scientific basis for further prevention and control of HFMD.Methods The epidemiological and etiological data of HFMD in children in the First Affiliated Hospital of Xi'an Medical University from January 2018 to December 2022 were retrospectively analyzed,and descriptive statistical analysis was performed.Results From 2018 to 2022,a total of 625 children with HFMD were treated in our hospital,and the number of patients showed a decreasing trend year by year.The incidence of man to woman was 1.43:1,but there was no significant difference in sex ratio among different years(x2trend=3.389,P＞0.05).The patients were mainly children under 5 years of age,especially children 0～＜1 years of age(33.60％),and the incidence difference was statistically significant among all age groups(x2=70.358,P＜0.05).The incidence was mainly concentrated in July and November,and the monthly incidence difference was statistically significant(x2=567.889,P＜0.05).There were 220 cases with positive HFMD etiology,the positive rate was 35.20％.The constituent ratio of coxsackievirus B(CVB),coxsackievirus A16(CA-16)and enterovirus virus 71(EV71)were 51.13％,30.83％and 18.05％,respectively.In 2018,2019 and 2021,the infection of enterovirus CVB was the most common one,and in 2020 and 2022,the infection of CA-16 was the most common one,there were significant differences in enterovirus infection and enterovirus infection between different years(all P＜0.05).Conclusions The prevention and control of HFMD in the region should focus on children under the age of 5,as well as summer and winter festivals.For pathogens of HFMD infection,in addition to EV71 and CA-16,which have been paid more attention in the past,CVB and other intestinal pathogens should not be ignored.Prevention and control of HFMD should be targeted according to the epidemiological characteristics and predicted incidence trend.
Hand-foot-and-mouth diseaseEpidemiologyEtiologyEpidemic prevention and control
万方数据
维普
