The value of serum Bcl-2 and Bax levels in predicting pulmonary infection in patients with lung cancer undergoing chemotherapy
Objective To study the value of serum B cell lymphoma-2 protein(Bcl-2)and B cell lymphoma-2-associated X protein(Bax)levels in predicting pulmonary infection in patients with lung cancer undergoing chemotherapy.Methods Clinical data of 253 patients with lung cancer who received chemotherapy in the Nantong Hospital Affiliated to Shanghai University from May 2021 to May 2023 were retrospectively analyzed;according to whether pulmonary infection occurred after chemotherapy,they were divided into infected group(n=45)and non-infected group(n=208).The serum Bcl-2 and Bax levels were compared between the two groups before chemotherapy,after chemotherapy for 2 and 4 weeks,and the influence factors of lung cancer patients with lung infection after chemotherapy were analyzed;the predictive value of serum Bcl-2 and Bax levels was analyzed by receiver operating characteristic(ROC);the correlation between serum Bcl-2 and Bax levels and influence factors of pulmonary infection was analyzed.Results The serum Bcl-2 levels after chemotherapy for 2 weeks and 4 weeks in the infected group were significantly lower than those in the uninfected group(t=6.627,7.564),and the serum Bax levels were significantly higher than those in the uninfected group(t=7.810,8.253)(all P＜0.05).Logistic regression analysis showed that age,smoking,TNM stage,type of chemotherapy drugs,pre-chemotherapy albumin and grade Ⅲ to Ⅳ neutropenia,white blood cell count(WBC)and clinical pulmonary infection score(CPIS)were all influence factors for pulmonary infection in lung cancer patients after chemotherapy(all P＜0.05).The area under the curve(AUC)of serum Bcl-2 and Bax combined detection was 0.912 and 95％CI was 0.865-0.958,which were higher than those of serum Bcl-2(AUC:0.774,95％CI:0.702-0.846)and Bax(AUC:0.827,95％CI:0.770-0.884),and the sensitivity and specificity of combined detection were 81.50％and 91.10％,respectively,which were higher than 51.10％and 90.40％of serum Bcl-2 alone and 88.90％and 63.00％of serum Bax alone.Pearson correlation analysis showed that serum Bcl-2 and Bax were correlated with age,smoking,TNM stage,chemotherapy drug type,pre-chemotherapy albumin,grade Ⅲ to Ⅳneutropenia,WBC and CPIS scores(all P＜0.05).Conclusion There were many influence factors for lung infection in lung cancer patients undergoing chemotherapy,and the combined detection of serum Bcl-2 and Bax levels could be used to predict the occurrence of lung infection,and should be paid close attention to.
NETL
NSTL
万方数据
