The diagnostic value of SCr and Cys-C combined with urinary β2-MG on renal injury in patients with hepatitis B cirrhosis in decompensated stage
Objective To analyze the diagnostic value of serum creatinine(Scr)and serum cystatin C(Cys-C)combined with urinary beta-2-microglobulin(β2-MG)in assessing early kidney injury caused by hepatitis B cirrhosis in the decompensated stage.Methods A retrospective study of patients with hepatitis B cirrhosis in the decompensated stage treated in the Third Affiliated Hospital of Sun Yat-sen University from January 2021 to January 2023.According to patient history,clinical presentation,complications,and estimated glomerular filtration rate(eGFR),the patients were divided into 50 patients in the renal injury group[eGFR＜90 mL/(min·1.73 m2)]and 50 patients in the non-renal injury group[eGFR≥90 mL/(min·1.73 m2)].Another 50 healthy person were selected as the healthy group.One-way ANOVA was used to analyze the differences of the relevant factors among the three groups;Pearson correlation was used to analyze the correlation between SCr,Cys-C,and urinary β2-MG and eGFR in the three groups;multifactorial logistic regression analysis was used to construct the diagnostic model,and receiver operating characteristic(ROC)curves were plotted to assess the diagnostic efficacy of the combined test factors.Results The SCr,Cys-C and urinary β2-MG in renal injury group were significantly higher than those in non-renal injury group and healthy group(F=38.789,61.999,47.124;all P＜0.001).In renal injury group,SCr,Cys-C and urinary β2-MG were negatively correlated with the eGFR(r=-0.895,-0.893,-0.834;all P＜0.05).Their combined detection area under the ROC curve(AUC)was the largest(AUC=0.997,P＜0.001),higher than that of the single factor SCr(AUC=0.952,P＜0.001),Cys-C(AUC=0.966,P＜0.001)and urinary β2-MG(AUC=0.924,P＜0.001),and the sensitivity and specificity were 100％and 96％,respectively.Conclusion SCr,Cys-C and urinary β2-MG combined detection can be used as a relevant screening indicator for kidney injury in hepatitis B cirrhosis in decompensated stage,and was better than a single index.
Hepatitis B cirrhosisDecompensated stageRenal injurySerum creatinineSerum cystatin CUrinary β2-MG
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NSTL
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