Clinical characteristics and pathogenic bacteria distribution of maternal bloodstream infection
Objective To investigate the clinical characteristics,pathogen distribution and antimicrobial susceptibility test of maternal bloodstream infection,and provide reference basis for clinical diagnosis and treatment.Method A retrospective analysis was performed on the clinical medical records,pathogen distribution and antimicrobial susceptibility test of bloodstream infection cases in the obstetric ward of the Guangdong Provincial People's Hospital from January 2013 to December 2022.Results The data of 50 pregnant women with bloodstream infection were collected;44 patients(88％)were complicated with obstetrics and gynecology related diseases and complications;46 patients(92％)had fever in the course of the disease,and 2 patients(4％)had septic shock.All patients with bloodstream infection had elevated inflammatory markers during the course of the disease.All patients were cured and discharged after active treatment,but 6 cases(12％)had infectious abortion.Among 50 patients with bloodstream infection,a total of 57 pathogenic bacteria were isolated.The most common pathogens were 22 strains of Escherichia coli(39％),10 strains of Streptococcus agalactiae(18％)and 7 strains of Enterococcus faecalis(12％).The detection rate of extended-spectrum β-lactamases(ESBL)-producing Escherichia coli was 50％(11/22).The sensitivity rates of Escherichia coli to amikacin,imipenem and ertapenem were all 100％,and the resistance rate to ampicillin was the highest.The sensitivity rates of Streptococcus agalactiae to ampicillin,penicillin G,vancomycin,quinuptine/dafuptine and linezolid were all 100％,and the resistance rate to tetracycline was the highest.Conclusions Maternal bloodstream infection mainly occurred after delivery,which could lead to septic shock and septic abortion,and cause serious harm to maternal and infant health.The pathogens isolated from maternal bloodstream infection were mainly Escherichia coli,Streptococcus agalactiae,and Enterococcus faecalis.Antibacterial drugs should be rationally used and regulated according to the corresponding pathogenic bacteria and the results of antimicrobial susceptibility tests.
Bloodstream infectionMaternalPathogen distributionAntimicrobial susceptibility test
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