Preparation and properties of α-tocopherol nanoemulsions
To improve the stability and activity of α-tocopherol(α-Toc),a nanoemulsion was prepared by supramolecular inclusion method,which was a kind of nanocarrier for α-Toc with good stability,good transdermal effect and excellent anti-oxidation.The effects of the types of polysorbates(Tweens),the amount of hydroxypropyl β-cyclodextrin(HP-β-CD)and the amount of α-Toc solution on the particle size of the nanoemulsion were investigated.The encapsulation condition and performance evaluation of α-Toc nanoemulsion were studied by Fourier infrared spectroscopy,transmission electron microscopy,nanoparticle size analysis,thermogravimetric analysis and Franz diffusion cell method.The results showed that the obtained α-Toc supramolecular nanoemulsion had small particle size and uniform distribution and had good storage stability both at 0℃and room temperature.This nanoemulsion could significantly enhance the thermal stability of α-Toc,and it showed better antioxidant capacity than the nonencapsulated α-Toc.The nanoemulsion could also effectively promote the transdermal absorption of α-Toc in cosmetic formula.This work could provide research basis for the application of nanocarriers in the field of daily-use chemical industry.
α-tocopherolnano-emulsionsupramoleculeperformance study
国家科技期刊平台
NSTL
万方数据
维普
