首页|前体离子扫描超高效液相色谱-三重四级杆串联质谱法快速筛查化妆品中非法添加的磺胺类药物

前体离子扫描超高效液相色谱-三重四级杆串联质谱法快速筛查化妆品中非法添加的磺胺类药物

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磺胺类药物(SAs)为化妆品中禁用物质.采用超高效液相色谱-三重四级杆/复合线性离子阱串联质谱(UPLC-QTrap),利用前体离子-增强子离子扫描(PIS-IDA-EPI)模式,用于快速筛查化妆品中非法添加的SAs.选择三个碰撞诱导解离形成的产物离子m/z 92,m/z 108,m/z 156,对12种化妆品基质中的20个SAs进行PIS-IDA-EPI扫描分析,检出限LODs为0.05～0.1 μg/g,该方法在12批次化妆品加标样品中进行了验证,并测定了60批次化妆品样品,以确保其有效性、灵敏度和选择性.实验结果表明:UPLC-QTrap结合PIS-IDA-EPI采集模式是一种有效的筛查方法,并成功应用于化妆品样品中目标和非目标SAs的快速筛查.
Screening for illegal addition of sulfonamides in cosmetic products using ultra-performance liquid chromatographytriple quadrupoletandem mass spectrometry with precursor ion scanning
Sulfonamides(SAs)are prohibited substances in cosmetics.An ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-QTrap)method using precursor ion-information dependent acquisition-enhanced product ion(PIS-IDA-EPI)scanning mode was developed to screen SAs in cosmetics.Twenty SAs were investigated to identify their common product ions formed by collision-induced dissociation.Three common positive product ions,m/z 92,m/z 108,m/z 156 are selected for PIS analysis.Limits of detection(LODs)are 0.05-0.1 μg/g for all 20 SAs in 12 kinds of cosmetic matrix.Sixty samples are analyzed.An effective screening method using UPLC-QTrap with PIS-IDA-EPI acquisition mode is developed and successfully applied to screen for the targeted and untargeted SAs in cosmetic samples.

sulfonamides(SAs)cosmeticstriple quadrupole/composite linear ion trap mass spectrometry(QTrap)precursor ion scan(PIS)

芦丽、方方、冯有龙、曹玲

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江苏省食品药品监督检验研究院,江苏 南京 210008

磺胺类药物 化妆品 三重四级杆/复合线性离子阱质谱(QTrap) 前体离子扫描(PIS)

江苏省市场监督管理局科技计划项目

KJ207560

2024

10.3969/j.issn.2097-2806.2024.02.014

日用化学工业(中英文)
中国日用化学工业研究院

日用化学工业(中英文)

CSTPCD北大核心
影响因子：0.553
ISSN：1001-1803
年,卷(期)：2024.54(2)
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