Preparation of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel and its whitening and antioxidative effects
The 4-butylresorcinol-containing cinnamon oil microemulsion-gel was prepared and its pharmaceutical properties were investigated.Its whitening and antioxidant properties were evaluated.Cinnamon oil microemulsion containing 4-butylresorcinol is clear and transparent in appearance.Its particle size is 15.68 nm and the coefficient of dispersity(PDI)is 0.185.The microemulsion-gel is prepared by using carbopol and Bletilla striata(T.)Reichb.F.polysaccharides as the gel matrix with the pH value at 6.0 and the viscosity at 74.8 Pa·s.In this study,the whitening effect of 4-butylresorcinol-containing cinnamon oil microemulsion-gel was determined by measuring the tyrosinase inhibition.It is shown that the tyrosinase inhibition of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel gradually enhances with its concentration increasing.The tyrosinase inhibition activity of microemulsion-gels is higher than that of the free 4-butylresorcinol and arbutin at the same concentration.The antioxidant effect of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel on hydrogen peroxide(H2O2)-induced oxidative damage was tested in B16-F10 cells.The results show that microemulsion-gel has excellent antioxidant effect by reducing ROS production.
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