Preparation of Fe3O4 nanoparticles and its drug-loading and drug-release properties
Graphene oxide(GO)was obtained by the improved Hummers method.The GO/Fe3O4 composite,in which GO was combined with magnetic Fe3O4 nanoparticles,was prepared by co-precipitation method.The crystalline structure,microscopic morphology,magnetic properties and drug loading of the composite were analyzed.The results showed that:The GO/Fe3O4 composite had high crystallinity;GO doping improved the uniformity of Fe3O4 particles,and the grain size of GO/Fe3O4 composite was 13-15 nm.The GO/Fe3O4 composite exhibited superparamagnetic properties with a slight decrease in saturation magnetization.The drug-release properties were studied by using GO/Fe3O4 composite to load doxorubicin(DOX).The average encapsulation efficiency of GO/Fe3O4/DOX inclusion complex was 62.24％,which was quite high.The drug release showed pH dependence.When the pH was 7.4,the cumulative release rate reached 73.3％in 75 h.The cellular uptake test showed that the GO/Fe3O4 carrier had certain targeting properties and could be used as a good new drug carrier.
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